organization is filled with incompetent management scooped from the bottom barrel of the talent pool at other companies and relies on heroics from individual contributors to carry the burden of incometent managers.
Lost connection to manufacturing. The management decided to close the manufacturing plants. It has become a place doing often irrelevant work for the parent company. It has been also a source of personnel for smaller companies with disappointing results. These people taken out of their niches lack perspective of broad aspects of drug development process.