Lost connection to manufacturing. The management decided to close the manufacturing plants. It has become a place doing often irrelevant work for the parent company. It has been also a source of personnel for smaller companies with disappointing results. These people taken out of their niches lack perspective of broad aspects of drug development process.
The company I work for has an extremely toxic culture. Success is measured by how much ass you can kiss. The people in leadership positions are not subject to the same rules as everyone else and do not lead by example. The head of research is an absolute tyrant who protects his buddies. Its classic cronyism.