they’re trying to say it’s the first “topical biologic” but that’s a tough sell for me. Dupixent is going after patients where a topical is not advisable Or not adequate (IE: systemic therapy candidates) so it will likely be used as an add on for a topical when BSA involvement is high, if an area that is not ideal for a topical is affected (IE: head, hands, feet), or other factors Like age depending on how good of a sales person your Dupixent rep is. This will likely be competing more with Eucrisa & other topicals which will be much cheaper and likely much safer. One of the number one questionS you need to know that no one seems to have the answer to is how the safety profile changes when you reformulate a JAK inhibitor from a systemic treatment to a topical. Will the warnings that are being slapped on products like Xeljanz and the immunosuppressive qualities of the other JAK inhibitors come with the product in topical form? Food for thought...