MRL is dead

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I guess no one likes parmee and shiply because they promoted outsourcing and 5s.

5s is kinda silly. But i think many people took it out of context and made it more stringent than it had to be.

My opinion is that there is nothing wrong with the majority of our directors.

They were making the best of things with the worse executive leadership team on the planet.

The entire merck research org was dragged into the mud over the last several years by peter. Its going to take a decade to recover. And its going to take more re-orging.


Anonymous said:
What's wrong with Shipley ?
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Anonymous said:
Plan is to allow middle management to suck dry untill the money runs out. Bring back Ed, Roy, Robert, Ken, anyone with leadership and discovery experience. The culture of PROCESS must end. In desperate need of new leadership. Does anyone in control ask know what is happening on the ground? So disconnected but nothing has changed since RP came except losing good scientists. Didn't lose the poor managers.

Rumor moral is bad at WP. I'll tell you a secret - NOT a rumor! Stop the process and let the scientists be creative. You may be surprised what is discovered if we have some freedom and able to take risks without threat of jobs or becoming target.
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Agree. Where are the scientists I upper or middle management? Where are the people with drug discover success stories? Sad, very sad and depressing.
 






Anonymous said:
To the issues...... Last 4 years a disaster. Too much process and little freedom in labs to discover! No flex time on the bench just run assays. Outsourcing worked well (ha ha) many assays returned due to external capability and cost. Then the clean out 5S (AND no one accountable!). Metters cut after BRGOS, why not 5S cheerleaders? A far cry from the organization even 10 years ago. merger too! More people, more sites with every advanced molecule from the purchase a failure.
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Waiting for the axe to fall........ Cheerleaders not forgotten
 






Anonymous said:
MRL was world class. Now second tier. Most people in R&D know the travesty that has occurred within the labs over last 7 years. Great scientists gone, reputation and clout gone, productivity down, innovation gone, pride gone.
But all the drawers are labelled :)

Get rid of upper management that made this happen and maybe they can get back to where they were. Time is running out
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Tick tock. 3rd tier now. What was once a collaborative, motivated, well build infrastructure is now destroyed. Time to remove the problems, stabilize the troops and motivate and innovate until we reach the top.

Roger step up and make the calls. The bullpen better be warming up, we need a few good closers to get us out of the inning. Can't you see we want the company to succeed?
 






Just goes to show you that MRL is just plum out of ideas when it comes to using existing resources and scientists to advance the pipeline. The numerous posts on CP exclaiming the virtues of the RNAi effort at Merck in the past and yet nothing actually came of this technology purchase play. Buying Sirna for $1.1B in 2006 and then selling it all again for $175 million in cash and stock in 2014. Only five months following the sale of assets to Alnylam and they figure out at least one way to put these resources to work.

http://www.theflyonthewall.com/perm...ylam-names-new-program-ALNHBV-to-its-pipeline

"Alnylam names new program ALN-HBV to its pipeline
Alnylam (ALNY) announced that it has named a new program to its pipeline, ALN-HBV for the treatment of hepatitis B virus infection. The new ALN-HBV program derives from the company’s January 2014 acquisition of Merck’s (MRK) RNAi assets, including their Sirna Therapeutics subsidiary. In the most comprehensive proof-of-concept pre-clinical study results presented to date with an RNAi therapeutic for the treatment of HBV, Alnylam reported significant, multi-log reductions in HBV surface antigen and HBV viral titers, and showed evidence for an immune-mediated therapeutic effect in chronically infected chimpanzees. Alnylam plans to advance an ESC-GalNAc-siRNA conjugate targeting the HBV genome for its ALN-HBV program. An ESC-GalNAc-siRNA conjugate will enable subcutaneous dose administration with improved potency and durability, and a wide therapeutic index. The company expects to select a Development Candidate in late FY14 and plans to file an IND or IND equivalent around year end FY15".

Where is the MRL talent that is going to turn this company around or assess the potential success of any late program purchase needed to rebuild the pipeline? Will RP's plan to rebuild this company on the back of PD-1 actually have the legs?
 






Anonymous said:
Tick tock. 3rd tier now. What was once a collaborative, motivated, well build infrastructure is now destroyed. Time to remove the problems, stabilize the troops and motivate and innovate until we reach the top.

Roger step up and make the calls. The bullpen better be warming up, we need a few good closers to get us out of the inning. Can't you see we want the company to succeed?
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Is there anybody left that can deliver the Perlmutter vision? Is there any vision beyond PD-1? Can a successful PD-1 supplant all that has been lost? Enquiring minds want to know.
 












Anonymous said:
Plan is to allow middle management to suck dry untill the money runs out. Bring back Ed, Roy, Robert, Ken, anyone with leadership and discovery experience. The culture of PROCESS must end. In desperate need of new leadership. Does anyone in control ask know what is happening on the ground? So disconnected but nothing has changed since RP came except losing good scientists. Didn't lose the poor managers.

Rumor moral is bad at WP. I'll tell you a secret - NOT a rumor! Stop the process and let the scientists be creative. You may be surprised what is discovered if we have some freedom and able to take risks without threat of jobs or becoming target.
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Yes in agreement. Note mgt does not interact or ask about the situation. Even a comment section would be helpful
 












I just saw they have postings for postdocs at MRL. I'm about to graduate next summer and was thinking about applying. This thread makes me think that might not be a smart move...
 












Anonymous said:
I just saw they have postings for postdocs at MRL. I'm about to graduate next summer and was thinking about applying. This thread makes me think that might not be a smart move...
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It can be a good place to get your feet wet in the industry. Just don't plan on making a career out of it. You will soon be Mercked and then you will lose your drive and become part of the furniture.
 






Anonymous said:
I just saw they have postings for postdocs at MRL. I'm about to graduate next summer and was thinking about applying. This thread makes me think that might not be a smart move...
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A "Post Doc" ????
Do you know what a traditional Post-Doc relationship is !!!!!!!!!!???????????????????????
You have a Ph.D. in something???
Who the FUCK will you study with...what the FUCK will they teach you?????
Get real.....
Get a "job" or get a "post-doc" at a real learning and research institution.
 






MRL feels like a rotting corpse. Has anyone walked through WP lately? WTF happened to this once great R&D machine. Very little research anymore. most of the scientists are managing outside research projects. This company is consistently 10 years behind every other pharma out there.
 






Anonymous said:
A "Post Doc" ????
Do you know what a traditional Post-Doc relationship is !!!!!!!!!!???????????????????????
You have a Ph.D. in something???
Who the FUCK will you study with...what the FUCK will they teach you?????
Get real.....
Get a "job" or get a "post-doc" at a real learning and research institution.
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Curb the filthy language! It shows to the world what a one dementional research nerd you are, zip it.
 






Anonymous said:
MRL feels like a rotting corpse. Has anyone walked through WP lately? WTF happened to this once great R&D machine. Very little research anymore. most of the scientists are managing outside research projects. This company is consistently 10 years behind every other pharma out there.
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RY feels the same way. Empty parking lots, empty cafeteria, buildings closed and scheduled for demolition. Pity the poor souls moving here from Summit and WHS.
 






Anonymous said:
With all due respect to your naivete, surely you cannot be serious! Did you have the impression that MRL (or all of Merck for that matter) is some kind of "democracy"? LOL. Where opposing viewpoints are respected and considered? Where thoughtful difference of opinion or helpful suggestions were/are encouraged? Think North Korea, my friend. Three or four autocrats with limitless power and arrogance, and no accountability. And everyone else better march to their drums....or you're out on the street. Speaking up has always been/is suicide. At least for the past 8 years. That's why the really good, respected scientists voted with their feet. All that is left are 1) the handful of VPs who are given free reign to repeat the same mistakes over and over, 2) the yes-men and yes-women who are the Lean-Sigma and 5S enforcers, flooding everyone with stifling, unending process, and 3) the terrified bench scientists who have their hands chained, and dare not let out a peep. They know what happens to those that "peep".

RP has done nothing in this regard. The corrupt VP process-drivers and destroyers of research are still alive and well. It's no secret why innovation is dead and the pipeline has gone to sh!t.
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Well said. No one speaks up unless you want to become a target. Rap still can't gut theVP level. Next is ex dir level. Send em back!
 






Anonymous said:
I just saw they have postings for postdocs at MRL. I'm about to graduate next summer and was thinking about applying. This thread makes me think that might not be a smart move...
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Looking for cheap, but intelligent, labor. And will probaby try to milk you for your fellow classmate's projects, regardless who funded them. I agree...stay in academia. Merck is a scourge.
 






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