Let's play "Antibodies for Alzheimers!"

Quote




Risk factors include: low education levels, high blood pressure, smoking, obesity, physical inactivity, diabetes, excessive alcohol consumption, brain injury and air pollution.

We believe that several other factors that could have a positive impact will likely soon be added to the Lancet’s list: Consuming a Mediterranean diet, optimizing sleep, reducing stress, combating elevated blood levels of homocysteine with B-vitamins, managing high cholesterol and, for the right people (e.g., those with the APOE4 gene) and at the right dose, supplementing with Omega-3 fatty acids.

Opinion: Why aren't doctors telling patients these simple ways to reduce the risk of dementia? | CNN
 




anonymous said:
Risk factors include: low education levels, high blood pressure, smoking, obesity, physical inactivity, diabetes, excessive alcohol consumption, brain injury and air pollution.

We believe that several other factors that could have a positive impact will likely soon be added to the Lancet’s list: Consuming a Mediterranean diet, optimizing sleep, reducing stress, combating elevated blood levels of homocysteine with B-vitamins, managing high cholesterol and, for the right people (e.g., those with the APOE4 gene) and at the right dose, supplementing with Omega-3 fatty acids.

Opinion: Why aren't doctors telling patients these simple ways to reduce the risk of dementia? | CNN
Click to expand...

So, can a ~30% reduction in the progression of the disease be obtained by early sufferers, without the antibody treatments? Anyone from medical care to chime in?

It sure would be great to see a statistical study for non-pharmacologic interventions too, as a sort of benchmark, to keep us all honest. If we are not honest, we should not be selling at all.
 




anonymous said:
So, can a ~30% reduction in the progression of the disease be obtained by early sufferers, without the antibody treatments? Anyone from medical care to chime in?

It sure would be great to see a statistical study for non-pharmacologic interventions too, as a sort of benchmark, to keep us all honest. If we are not honest, we should not be selling at all.
Click to expand...

Sounds like a good thesis topic. Not sure that this sort of analysis belongs in a for-profit institution, however.

Sure, a cost-benefit analysis weighted with economic costs associated with somewhat risky pharmacologic interventions vis-a-vis lifestyle (diet, exercise, social, educational, etc) interventions, why not?
 




anonymous said:
Sounds like a good thesis topic. Not sure that this sort of analysis belongs in a for-profit institution, however.

Sure, a cost-benefit analysis weighted with economic costs associated with somewhat risky pharmacologic interventions vis-a-vis lifestyle (diet, exercise, social, educational, etc) interventions, why not?
Click to expand...

Honesty v. Greed, Corruption, Lies, & Deceit

Judge Bought Andpaidfor will have the honor.
 




















anonymous said:
Someone on this thread needs serious therapy.

Maybe you’re just the competition who is scared shitless about the whipping you’re going to get!
Click to expand...

Sure, drug them into oblivion or worse. It worked with Zyprexa. Pride cometh before the fall (and multibillion dollar lawsuits). There are conscientious Lilly employees. But not in high level management, it seems. Prove me wrong.
 




anonymous said:
Sounds like a good thesis topic. Not sure that this sort of analysis belongs in a for-profit institution, however.

Sure, a cost-benefit analysis weighted with economic costs associated with somewhat risky pharmacologic interventions vis-a-vis lifestyle (diet, exercise, social, educational, etc) interventions, why not?
Click to expand...

Why not? There is no big money available for such studies without a future ROI. The true cure for alz and dementia is most likely diet and exercise earlier on in life ( carb intake+ high-energy diet, growing insulin resistance, nafld, ascvd, and much later on amyloid buildup, all of this is of course highly related), but no one is going to pay for that long-term study. Best chance for a viable therapy is most likely a glp-1RA, but unfortunately it's not looking like one from Lilly, at least not at this time. Just being honest here.
 








anonymous said:
Why not? There is no big money available for such studies without a future ROI. The true cure for alz and dementia is most likely diet and exercise earlier on in life ( carb intake+ high-energy diet, growing insulin resistance, NAFLD, asked, and much later on amyloid buildup, all of this is of course highly related), but no one is going to pay for that long-term study. The best chance for a viable therapy is most likely a glp-1RA, but unfortunately, it's not looking like one from Lilly, at least not now. Just being honest here.
Click to expand...

At what age will it be acceptable to die? Is it possible to expire with ALZ and still have a rewarding life? I think it is. A. The world is overpopulated. B. You're going to die. C. Focusing on ALZ is a blatant money ploy.
 




The St. Louis scientists have also demonstrated in a series of experiments that sleep deprivation prevents immune cells known as microglia from properly cleaning up deposits of amyloid protein during the sleep cycle, a finding that helps explain the long-observed connection between sleep loss and neurodegeneration. Amyloid proteins are the building blocks of gooey amyloid plaques, a key hallmark of Alzheimer's disease.

In their research, which is reported in Science Translational Medicine, the team turned to multiple mouse models to show how disrupted sleep patterns allow deposits of amyloid to accumulate. Sleep is biologically beneficial to the brain because that's when an elaborate network flushes away excess amyloid as well as cellular and metabolic debris. Without that daily clean-up cycle, the brain can pay an enormous price.
 
















The researchers found 32 proteins that, if dysregulated in people aged 45 to 60, were strongly associated with an elevated chance of developing dementia in later life. It is unclear how exactly these proteins might be involved in the disease, but the link is “highly unlikely to be due to just chance alone”, says Walker.

“Not all the proteins showed changes in both plasma and brain tissues,” says Nicholas Seyfried, a biochemist and neurologist at Emory University in Atlanta, Georgia. For example, one of the proteins found with the strongest association with dementia risk — called GDF15 — was not detected in the brain, suggesting that “mechanisms below the neck could also play a role”, he adds.

Don't get stressed .... Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint
 












Top Bottom
Back
Quote