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Esperion

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So wtf lol on this bempadoic acid...I asked a number of my cardiologists and a few PC’s who are more aggressive with treating CVD- none had heard of it. One cardiologist did a google search and honed in on the late trial deaths seen on BA arm vs placebo with weak efficacy results. Nice headline Esperion. Wanna know what drug they’ve all heard of and were visibly excited for? Incliseran. Good luck with this goofy pill.
 








anonymous said:
https://www.fiercebiotech.com/biote...3-ldl-study-raises-flags-treatment-arm-deaths

This drug is riding on a side effect profile to win? Efficacy barely as good as pennies-on-the-dollar statins but has already shown late stage trial data with more deaths in the active drug arm than placebo? Convince me otherwise.
Click to expand...

I’m with you. When was the last time that you heard a company doing a sales force buildout using terms like if the drug is approved or “offers are contingent on drug approval”. I’m guessing that they already have millions tied up with severance packages for the district errrr regional managers and cannot risk the extra burden of the expense that a 300 person sales force would require. Then again if the approval was a certainty they would be training now with the goal to be knocking on that first door at 8am when the drug is approved. Using logic, approval has to be in question.
 




I have a few thoughts: I was contacted early on, back in October. I’m with Amgen. I took the call because I always take calls. Drug looked promising, the potential offer would promised to be aggressive. I spoke to RD 2-3 more times. Fast forward to late December, Praluent reps being laid off changed everything. So when I still decided to interview in person last week, I did so knowing I would not get an offer. I was too expensive...and I was OK with that. For me, it was a chance to keep my interview skills sharp and make a positive impression for opportunities down the road. I interviewed well, as most other do, and was told I’d hear back in 5 days. Today is day 6 and I haven’t heard anything. It’s obvious I’m not getting an offer and I’m fine with that. But no communication at all is really bad form. And I hope I don’t get some generic email either. Considering how long this process has been, I took an entire day off and drove 3 hours for an interview, the RD should call me and let me know I wasn’t the best fit. It’s a matter of decency and respect. I’m not bitter, just annoyed by lack of respect
 




anonymous said:
I have a few thoughts: I was contacted early on, back in October. I’m with Amgen. I took the call because I always take calls. Drug looked promising, the potential offer would promised to be aggressive. I spoke to RD 2-3 more times. Fast forward to late December, Praluent reps being laid off changed everything. So when I still decided to interview in person last week, I did so knowing I would not get an offer. I was too expensive...and I was OK with that. For me, it was a chance to keep my interview skills sharp and make a positive impression for opportunities down the road. I interviewed well, as most other do, and was told I’d hear back in 5 days. Today is day 6 and I haven’t heard anything. It’s obvious I’m not getting an offer and I’m fine with that. But no communication at all is really bad form. And I hope I don’t get some generic email either. Considering how long this process has been, I took an entire day off and drove 3 hours for an interview, the RD should call me and let me know I wasn’t the best fit. It’s a matter of decency and respect. I’m not bitter, just annoyed by lack of respect
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Not every person or organization has class. E, the lipid company (what a joke) is not a firs class company and will likely fail to exist within your career lifetime. Thank goodness you didn’t really need a job; it’s a fly by night seat of the pants bullshit operation.
 




Ive got one for you. During interview manger asks for rankings. Here's my new question i will ask of any hiring manager after I answer that question. "Can I see what your last rating was? Can I take a look at your previous 3 years of reviews? Can I call your superior?"

I've done some background search on several of these "regional" managers. The ones Ive seen look like they were either let go, were going to be let go, or just plain old didnt do well. They certainly are job hoppers-a sure tell sign of problems. Then they have the fucking balls to as us about our rankings and reviews.

This is a piss poor, no class organization who will terrorize their new employees with unrealistic sales quotas. With a less than stellar drug. Think Zetia. Good luck to you folks. You have a bunch of clowns running the show, none of them knowing what to do next.
 




anonymous said:
It's all about outcomes when it comes to CVD. That means it will be a slow fight until and if outcomes pan out favorably. I'm thinking itll be a last add-on option when all else fails....statins, zetia, pcsk9s, vibrates, omega 3, etc.
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Count on counting your number of weekly scripts on one hand 18 months post launch (if it makes it)
 




anonymous said:
Ive got one for you. During interview manger asks for rankings. Here's my new question i will ask of any hiring manager after I answer that question. "Can I see what your last rating was? Can I take a look at your previous 3 years of reviews? Can I call your superior?"

I've done some background search on several of these "regional" managers. The ones Ive seen look like they were either let go, were going to be let go, or just plain old didnt do well. They certainly are job hoppers-a sure tell sign of problems. Then they have the fucking balls to as us about our rankings and reviews.

This is a piss poor, no class organization who will terrorize their new employees with unrealistic sales quotas. With a less than stellar drug. Think Zetia. Good luck to you folks. You have a bunch of clowns running the show, none of them knowing what to do next.
Click to expand...


think extra 16 percent lower LDL over Zetia. Nobody is going to pay a premium for that. That’s why they have a bunch of losers running the company.
Nobody with a viable career would jump into this shit show.
Probably won’t even get approved.
 




TO ALL THOSE STILL INTERVIEWING!! Here’s the key to an offer...walk in to the conference room and present a one page, one line “business plan.” It reads:
‘I _________(first name) _______(last name), commit to 500 scripts per week during the first 30 days of launch regardless of indication, MC coverage, territory alignment, HCP names, budget and sample allocation.’

Guaranteed an offer on the spot.
 
















anonymous said:
So wtf lol on this bempadoic acid...I asked a number of my cardiologists and a few PC’s who are more aggressive with treating CVD- none had heard of it. One cardiologist did a google search and honed in on the late trial deaths seen on BA arm vs placebo with weak efficacy results. Nice headline Esperion. Wanna know what drug they’ve all heard of and were visibly excited for? Incliseran. Good luck with this goofy pill.
Click to expand...

same here.....it’s called smoke and mirrors
 




Who all attended the first day in Dallas? It seemed as though everyone I spoke to received the same call with similar verbiage. I was told you are not out of the running hang tight for the next steps. Others were told you will hear in about 3 to 5 business days. It seemed as though no one met the National in person due to the overwhelming amount of candidates needing to be presented for one guy. Anyone else experience the same?
 




anonymous said:
Who all attended the first day in Dallas? It seemed as though everyone I spoke to received the same call with similar verbiage. I was told you are not out of the running hang tight for the next steps. Others were told you will hear in about 3 to 5 business days. It seemed as though no one met the National in person due to the overwhelming amount of candidates needing to be presented for one guy. Anyone else experience the same?
Click to expand...

Oh God yes. Same exact bullshit that happened in LA. You my friend are being strung along while they take your experience, relationships, and any other valuable information they can in order to hire a less tenured, less expensive millennial. Thats the exact same verbiage that I heard.

I had one of the busiest cardiologists look at BA. His comment? "That's it?"
End of story
 








Was at a recent "hiring event". Was downsized at Regeneron and agressively recruited to attend. Ended up just filling a spot as there was no way they were going to pay me what I needed- they ended up hiring a candidate with limited CV experience for much less $$. Pretty sure I dodged a bullit. Several red flags: 1. Product: yeah, its "new" and "novel", but it's also uproven, with no compelling clinical data AND it's really just a Zetia knock off- the efficacy is no better. Lots of talk about the fixed dose combo, but they are initially launching the mono product only....if that bombs, will the fdc will follow? This drug will be going head-to-head with generic statins (the most proven drug class ever), ezetimibe (very well establsihed), PCSK9i- Amgen and Repatha, and soon, inclisiran, from Novartis- 2x/year, very cost effective, and the agent cardiologists are really waiting for. Sounds like an uphill battle- espeically for a start-up with limited $ and resources. 2. Process: the interview process was completely superficial- very little about the drug, clinical data (not much there) or disease state (other than something we already know: lots of people aren't at their LDL goals). Had 2 interviews and all they wanted to know was what I was going to do on day one, including the names of clinics and doctors I would call on, and, how many scripts I would bring in the first week, month and at 90 days. They want you to believe the culture won't be "big pharma" or about "metrics", but that's exectly what it will be- the pressure is going to be constant and intense. Furthermore, during the second interview, with a couple dudes who were supposed to be "regional" or "national" managers, they were feverishly writing down doctors names as I said them. When was the last time this happened to you in an interview? Lame? Desparate? Unprofessional? All of the above. 3. Company: from everyhting I can tell, they barely have enough capital to launch, and they are going to need huge Rx volume out of the gate to keep it going. Keep in mind- new company, one drug, competing in a crowded, highly competitive, highly clinical, cost sensitive space. Finally, and maybe most importantly, the whole thing is being run by LAWYERS- a handful of people who have invested (supposedly) 10 years of their lives into this thing. Bottom line: they want their time and money back ASAP, and they'll do/say anything to get the company to the point where they can sell it off, and that will be that. My take: be afriad and stay away.
 




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