Trulicity

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Anonymous said:
this drug is awful, so far every dr. i've had write a scrip, has had a patient complain about awful sickness and vomiting. I feel like I've been spending more time reporting AE's then selling....

This class is stacked, so why would a Dr. write a drug that he knows will make his patients sick? This nausea is going to destroy the drug.

someone mentioned that they under reported nausea in trials... I believe it because I'm seeing something closer to 50%-65% of the patients reporting nausea, not 20% like the studies claim.
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Just goes to show, HONESTY is THE BEST and should be the ONLY POLICY

Once that's gone, everything just degenerates.

Oh but we have some sexy 20-something guys and gals who can assemble a Six Sigma team to smooth over these missteps.... sorry.... not this time...............

Oh and SPOTLIGHT POINTS can be spread around to hush the chatter... sad, very very sad
 






The device is only one aspect. Tolerability, patient access, and affordability all have a place in the physicians decisions. If we are only selling the ease of our device, we will lose the GLP-1 battle. Bydureon has a long track record and is on just about every managed care plan. Tanzeum is well tolerated and they are giving it away. We need to have another selling point or we will lose.
 






Another selling point won't help. What you need is a different drug. Let Trulicity fall into the trash bin of bad drugs and start over with something new. But then that would require some real innovation and science.
 












The company is not hanging its hat on Trulicity. Yes, we have a great device...but...it's in a crowded and competitive market space. Any of you guys remember the antibiotic wars? Augmentin, Ceclor, Lorabid, Cefzil, Ceftin, Suprax, Biaxin, etc. History has a funny way of repeating itself. Even if we get half the market (which we won't) there are others i.e. Bydureon, Tanzeum, and Victoza which will still get a chunk of the market. Personally, I believe the market for GLP-1s will grow. Seems like every other day the SGLT-2s have some safety issue. Trulicity is a me too. A high priced one at that.
 






Anonymous said:
Another selling point won't help. What you need is a different drug. Let Trulicity fall into the trash bin of bad drugs and start over with something new. But then that would require some real innovation and science.
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Indeed. So many in LRL leadership need to undergo random drug testing. They believe that our "Science Fiction Double-Feature Pipeline Show...from a CRO" is going to deliver anything more than dust.
 
























Type 2 who's been on Byetta / Bydureon since 2007. I can tell you the Bydureon injection _sucks_. Hurts like getting blood drawn every week, plus 5-10 minutes of tapping and sloshing to get the powder into suspension. Annoying the point that I've thought about going back to the 2x daily Byetta pen, but I do get significantly better control with the weekly, and I do a lot of business travel and dealing with the pen, avoiding heat (I'm sometimes in tropical countries) and needing to shoot myself up at specific times is a hassle. But shooting up with sticky syrup through a 23 gauge needle, not to mention being covered with nodules, also sucks.

On delivery, I'd imagine a heck of a lot of Bydureon users would jump for something better -- and "better" is a low bar.

On the other hand, projectile vomiting does not make for a good business meeting....

Was actually going to get a Trulicity scrip at my endo appt this month, but what I'm reading here and elsewhere about much worse GI side effects than exenatide or Victoza has given me pause. Will have to do more research on this. Crap, I was really hopeful.
 






Full Disclosure: I am a TX patient with no pharma experience. I'm a non-insulin dependent diabetic who was on Metformin a long time. My A1C was rising, so put me on a Jentadueto/Jardiance combo that worked extremely well for me. I saw an endocrinologist who thinks Jardiance may be contributing to recurrent yeast and UTIs, due to dumping sugar into the urine, so she put me on a Metformin/Trulicity combo. I've been on it for 2 weeks. The injection is super easy and almost entirely painfree--less painful than the finger sticks for blood testing. The side effects are definitely a downer--many bouts of nausea and unpredictable diarrhea, as well as general malaise, achiness, fatigue, heartburn and sweats. I've also had a headache for several days, but that may be unrelated. I'm still hopeful that these symptoms might diminish, and I'll give it a few more weeks to see. The potential for pancreatitis and thyroid tumors is another troubling factor. It is true that the above symptoms greatly diminish appetite and will likely contribute to weight loss. (hah!) Any nausea I had with oral diabetes meds listed above was largely controlled by taking with food and water. Trulicity is different and thus may be a harder sell for patients. Just my honest FYI. Whether it is put on the formulary and is affordable will also be a huge factor in whether I stay on it. Right now, I've met my 2015 OOP and don't have to pay for it. This thread is both troubling and informative. I know you have families to support and this is a business for you, but that shouldn't trump quality of patient care. Being honest about potential side effects up front might actually make more patients willing to stick it out and see whether the benefits outweigh the side effects/risks.
 






I'm not a sales person, I'm a patient. I've taken Bydureon for a year with good results. My sugar is under good medical management; unfortunately, Caremark has taken Bydureon off its approved drug list for 2016, so I've started taking Trulicity. I just took my third shot and the side effects seem to be getting worse. The nausea is debilitating; I've never experienced anything like it before. I wanted to give the drug a month, to see if the side effects lessen. I was confident I wouldn't have any of the gastro complaints, since I hadn't had any with Metformin or Bydureon. This stuff is poison, though. I'm not battling cancer; I have diabetes. There's just no pay off for me to keep using it.
 






anonymous said:
I'm not a sales person, I'm a patient. I've taken Bydureon for a year with good results. My sugar is under good medical management; unfortunately, Caremark has taken Bydureon off its approved drug list for 2016, so I've started taking Trulicity. I just took my third shot and the side effects seem to be getting worse. The nausea is debilitating; I've never experienced anything like it before. I wanted to give the drug a month, to see if the side effects lessen. I was confident I wouldn't have any of the gastro complaints, since I hadn't had any with Metformin or Bydureon. This stuff is poison, though. I'm not battling cancer; I have diabetes. There's just no pay off for me to keep using it.[/QUOTE
Yes, I'm a patient. Really I am
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Anonymous said:
Indeed. So many in LRL leadership need to undergo random drug testing. They believe that our "Science Fiction Double-Feature Pipeline Show...from a CRO" is going to deliver anything more than dust.
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CROs are great places for developing more .... hopium

I have seen the insides of these places. All they are concerned with is getting away with less than 50-60 hours per week. Top heavy management, just like here.
 






Lilly retiree and new Trulicity patient. End of week one but NO problems so far. Pen is great. Small needle makes it almost painless. Fasting blood levels down to target area. I'm on the low dose. Wonder if those having trouble were started on the higher one.
 


















I had 1 shot, sample at the dr office. had terrible pain in the back around my waist, urgent need to urinate, and not go much. and I wasn't at home yet. The next day, I had the projectile vomiting, which I have never had or vomited so violently. Day 3 and I still have nausea really bad. Then reading the side effects of cancer in rats, Im not sure I will continue on this. I rather have Diabetes and be heavy than to get cancer.
Like to hear your thoughts.
 






anonymous said:
I had 1 shot, sample at the dr office. had terrible pain in the back around my waist, urgent need to urinate, and not go much. and I wasn't at home yet. The next day, I had the projectile vomiting, which I have never had or vomited so violently. Day 3 and I still have nausea really bad. Then reading the side effects of cancer in rats, Im not sure I will continue on this. I rather have Diabetes and be heavy than to get cancer.
Like to hear your thoughts.
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You are having an adverse drug reaction. This should be reported to the FDA, and you should ask your doctor to do this...most doctors don't want to bother with the paperwork, but it is important for them to report these reactions. Stop taking this medication.
 






I'm not a sales rep, just a patient. I received trulicity and took a shot 10 days ago. Nauseated all week. The 6th day past the shot, I puked all day and had explosive diarrhea for nearly 24 hours. This is the 10th day, and it's starting up again. First the diarrhea, now horrible belching and then comes the vomiting. I wish I had never injected this crap. I thought metformin was bad...
 






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