Unfortunately, this was all very predictable based on decisions made by Mammen and Snellgrove starting in 2018. Combined, they managed to come in and destroy a decade of growth all because of ego. Hait and Stoffels combined with Picariello as CFO led R&D to deliver more than 2 NMEs per year for over a decade while avoiding the boom/bust common in the Pharm industry. Mammen and Snellgrove came in and proceeded to knock it all down to build “a better R&D org”, also knocking the prior leaders at every opportunity. Heavy handed management exact opposite of what they inherited, they choked out the culture. The result? NOTHING!!! Sales are still being driven by old NMEs from Hait/Stoffels era. Mammen shifted money away from portfolio to data sciences and other personal play areas and Snellgrove’s heavy handed and biased budget cuts undercut the very model that had R&D humming before his arrival. What happens to him, promoted to CFO for all of Pharm, and what happens, the rest of the business now follows R&D. At least Mammen was ousted, though more likely due to sexual harassment suit than recognition of incompetence. Sad to see that 2 narcissistic ego maniacs were capable of destroying all that Stoffels built. Those who experienced both worlds, felt the difference and knew this was coming. Pharm cycle is long and results of their actions from 2018 are just being felt now. As said, very predictable with no easy or short term fix possible.