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Lay-offs start December 1st - You heard it here first!

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Actos Recall Warning said:
The TZD Market is going to be completely pulled by the FDA on November 15, 2007 when final results come from the remaining two meta-analysis reports.

There are far too many alternative type treatments in place to manage and control type II diabetes at this time for the Food and Drug Administration to keep overlooking the huge potential side effect profile of the class of drugs called Thiazolidinedione (TZD).

TZD was first brought to market under the generic name: Troglitazone and trade name: Rezulin in the late 1990s by Parke Davis and Sankyo Pharmaceutical Companies and then withdrawn by the FDA on 21 March 2000 due to an increased incidence of drug-induced hepatitis that led to many deaths.

http://www.fda.gov/bbs/topics/NEWS/NEW00721.html

Earlier in 2007 both Actos and Avandia released two seperate black box warnings about potentially dangerous side effects: warnings about a condition in which the heart does not adequately pump blood. And an increased incidence of bone fracture was noted in female patients taking pioglitazone.

http://www.medicalnewstoday.com/articles/73582.php
http://www.medindia.net/news/view_news_main.asp?x=19105

Tomorrow, September 29, 2007 a leading Medical Journal called The Lancet is going to reveal startling results about another potentially deadly side effect concerning both the generic: Pioglitazone trade name: Actos and the generic: Rosiglitazone trade name: Avandia.

http://www.bloomberg.com/apps/news?pid=20601202&sid=aPjZWUdkCqLY&refer=healthcare
http://www.thelancet.com/journals/lancet/article/PIIS0140673607615141/abstract
http://health.yahoo.com/news/179829;_ylt=An9Cro5ZEur45MZwmJPCbVKmxbAB
http://www.fda.gov/Medwatch/SAFETY/2007/safety07.htm#actos
http://www.fda.gov/Medwatch/SAFETY/2007/safety07.htm#rosi_pio
http://www.fda.gov/bbs/topics/NEWS/2007/NEW01683.html
http://www.fda.gov/cder/drug/InfoSheets/HCP/rosiglitazone200707HCP.htm
http://www.fda.gov/cder/drug/InfoSheets/HCP/pioglitazoneHCP.htm
http://www.nlm.nih.gov/medlineplus/news/fullstory_55439.html
http://health.usnews.com/usnews/hea...s-drugs-boost-heart-failure-but-not-death.htm
http://www.healthcentral.com/heart-disease/news-160944-31.html

Another "rumor" has recently surfaced in this past week alone that Actos is possibly increasing the rate of bladder cancer and investigations have immediately started exploring this concern.

---On a nother note, but related overall to this subject:

President Bush just signed into law Thursday September 27, 2007 the final agreement that allows the FDA the power to remove unstable and unsafe drugs from the United States of America prescription profile.

http://news.yahoo.com/s/ap/20070927/ap_on_go_pr_wh/drug_safety

Today, September 28, 2007 the FDA immediately went into action with this new power and gave all drug companies world wide 30 days to remove any drugs that they are selling in the United States of America that are Unapproved by the FDA and considered cough medicine that contain hydrocodone and marketed to children

http://health.yahoo.com/news/179866;_ylt=ArqEnaX9VY2EKLYzJmKj16ymxbAB

Every year, doctors write approximately 65 million prescriptions for drugs not yet approved by the U.S. Food and Drug Administration, the federal agency that regulates prescription drugs.Apparently there are many drugs that fell into what was termed a "FDA Black Hole" and somehow slipped through federal regulated guidelines for specific metrics of gaining approval.

http://www.cnn.com/2007/HEALTH/conditions/09/26/unapproved.drugs/index.html?iref=mpstoryview
http://www.fda.gov/cder/drug/unapproved_drugs/

---late breaking news today announced a ground breaking step forward in the quest to make patient care the safest possible by the actual elimination of drugs that are linked to organ failure and/or even death.

It was also announced today that the 7 of the top Pharmaceutical Companies in the World will be coming together in an unprecedented meeting to compare unsafe side effect profiles of all the top selling products. The symposium is dubbed, International Severe Adverse Events Consortium. It is very odd that Takeda TPNA has opted not to participate in this forum, while their main competitor in the Type II Diabetes Market, GlaxoSmithKline is enrolled and ready to go to work in concert with the other 6 companies. The US FDA is applauding this effort to move forward in ensuring safetiness and compliance for all patients that suffer from a broad stroke of many disease states.

http://www.cnbc.com/id/21002275/for/cnbc
http://www.iht.com/articles/2007/09/27/business/drug.php
http://www.pharmatimes.com/WorldNews/ViewArticle.aspx?id=11853

---And on one final note concerning both Actos and Avandia:

The FDA seems to have had ample evidence about the risks associated with Actos and Avandia. In 2006, FDA drug safety advisor Dr. Rosemary Johann-Liang urged the agency to add a black box warning to Actos and Avandia because of serious cardiovascular risks. Instead of heeding her warning, however, the agency reprimanded Johann-Liang and did nothing to adequately inform consumers about the possible risks associated with Actos and Avandia.

So for those of you nay-sayers that point fingers at Dr. Steven Nissen's claim that Actos is safer than Avandia has been now singled out as actually being paid large sums of research money by Takeda. If you actually think that Avandia is going bye bye and Actos is untouchable, I would highly recommend that you stop drinking the kool-aid and realistically start thinking about your future in terms of having employment.
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OP's post was from 9-27-2007 and still no layoffs. Actos is still going strong. This post just proves how little people really know on this board!!
 




Look around. Actos going generic in less than a year. Rozebo and Uloric ar dead beat meds. Alo getting pushed and isn't going to be approved in the next 12 months. BMS's DPP-4 just approved to flood market even further. Bought Millinium for 8.8 Billlion that Takeda reps will not be carring there meds. Sorry to be harsh but these are just the facts. If you don't think its going to happen well good luck. Takada is on its last leg.
 








Anyone want to still bash on the Original Poster and his "Takeda Manifesto" ?

He may have not been correct about the original dates for a lay off, but his post always made sense if you really took the time to read them.

Almost everyone bashed him and said that Takeda has a strong history of never laying off anyone and that this was just a scare tactic and that he was full of shit...Because upper management kept stating that there would never ever lay off anyone...The Japanese business model never includes any type of down sizing ---> You were part of the Takeda family and you would always be protected ---> mainly due to the incredible pipe line of novel blockbuster potential drugs that would bring job security for many, many years to come.

So, the Original Poster was trying to warn all of us...Not scare us.

I wonder how many of you recently laid off people, now wish you would have taken the timne to read his 1st posting and really tried hard to understand it. I wonder if you had done that, then you probably would have had a real good head start in protecting your career in the pharma company...And not wait until this past June 15th and pretend to be "surprised" that TPNA could have done this to you.
 
























Anonymous said:
6 mo. ago??? it's dated "yesterday", and I like the taste of the kool aid...it's keeping the bills paid for now.
Click to expand...

im not going to read the 206 posts, but u are all r*****s... if u didnts see the writing on the wall when then natonal sales meeting was called off and pods were not being filed back to 3 you have it coming....... leave pharma and get intomed device or garbage...easy for me to say,i was cut tuesday as got a job with 4k raisse from you fuckerrrss in a week!!! haha suck it ******s!!!!!!
 








Anonymous said:
im not going to read the 206 posts, but u are all r*****s... if u didnts see the writing on the wall when then natonal sales meeting was called off and pods were not being filed back to 3 you have it coming....... leave pharma and get intomed device or garbage...easy for me to say,i was cut tuesday as got a job with 4k raisse from you fuckerrrss in a week!!! haha suck it ******s!!!!!!
Click to expand...



I hope it wasn't for a proof-reader, editor, or spelling teacher.
 




Anonymous said:
im not going to read the 206 posts, but u are all r*****s... if u didnts see the writing on the wall when then natonal sales meeting was called off and pods were not being filed back to 3 you have it coming....... leave pharma and get intomed device or garbage...easy for me to say,i was cut tuesday as got a job with 4k raisse from you fuckerrrss in a week!!! haha suck it ******s!!!!!!
Click to expand...

it's good to see at least one of the layoffs wasn't in vain...
 








Let's stop the sophomoric bickering and get back to the business of figuring out how to find a new job after the carnage. I left the company two months ago, and have two interviews lined-up in the next couple of weeks. One is a specialty pharma job, the other is a medical disposables sales position.

I was able to get both interviews through recruiters who posted these jobs on the Gorilla Medical job board. I really like this web site. It charges a fee to join, but it has been well worth the money spent. Good luck to any present and future reps leaving the company.
 




















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