[size=+3]Diabetes drugs double women's fracture risk
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By Mary Brophy Marcus, USA TODAY
Long-term use of a popular class of oral diabetes drugs doubles the risk of bone fractures in women with type 2 diabetes, a new study reports.
According to researchers at Wake Forest University School of Medicine who reviewed 10 previous drug trials, for every 20 women in their 70s with type 2 diabetes who took thiazolidinediones — rosiglitgizone (brand name Avandia) and pioglitazone (brand name Actos) — for at least one year, one of them has a chance of suffering a fracture. In women in their mid-50s, the figure equals one fracture in every 55 women. That's more than double the normal risk for those age groups.
The new research appears online in the Canadian Medical Association Journal this week. About 14,000 patients were involved in the studies analyzed by study co-author Sonal Singh, assistant professor of internal medicine at Wake Forest, and his colleagues.
The same increase in fractures was not found in men, says Singh, though the reason why was not determined.
"You always weigh the good effects and the not-so-good effects," says study co-author Curt Furberg, professor of public health sciences at Wake Forest.
He points out that researchers now know that the drugs increase the risk of heart failure and the risk of fractures in women. The Food and Drug Administration last year ordered black box warnings on both drugs' labels against their use in patients with advanced congestive heart failure. Avandia has been shown to increase the risk of heart attacks as well.
"So it's very much a gamble to take the drugs," Furberg says.
http://www.usatoday.com/news/health/2008-12-09-diabetes-actos-avandia_N.htm