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Lay-offs start December 1st - You heard it here first!









































I love the way you scumbag Takeda reps get so ethical when Actos gets hit hard with bullshit data. The reps in my area have been spreading lies and rumors about Avandia . We will have a job if Avandia gets pulled, you half ass Takeda reps will not. The industry knows how poorly you are trained and how unehtical you promote your products. Good luck finding a job loser.

If you are so ethical, maybe you should consider informing your customers of the new ADA/EASD guidelines that *twice* state that your drug should not be used...who's unethical?!?
 




If you are so ethical, maybe you should consider informing your customers of the new ADA/EASD guidelines that *twice* state that your drug should not be used...who's unethical?!?

Do you know the difference between a guideline and an opinion? Drop your pants turn around and look in the mirror..that's an opinion..everyone has one. In addition, don't be so quick to promote these "guidelines". If you read them you'll see that they have no favoritism toward's TZD's in general. They basically state that Avandia is not reccomended, but Actos should only be used for truck drivers and pilots..ie for when hypoglycemia is a concern. We should not be pushing against the class right now...it has not done any good.
 








The Lay-offs have now been pushed back to January 19th because of HR issues implementing a massive downsizing.

"There are now numerous reports that we may be heading towards a depression. Both Japan and America have an increasing amount of debt do to the recent decline in the stock market coupled with Takeda's delayed decision to shrink its salesforce to match moves by larger pharmaceutical companies such as Pfizer and Sanofi-Aventis." As you know Forbes recently wrote an article citing a potential 55% net loss in operating profit and recently posted its first profit decline in 16 years. Top executives know that we must decrease our operating costs by trimming the sales force. This may not seem logical except when you compare the recent reduction in sales force by other large pharmaceutical companies. A temp agency was recently hired to help prepare the paperwork which HR will mail after the reduction in sales force is announced early January."
 




Actos And Bone Fractures In Women

By Ed Silverman // December 11th, 2008 // 7:10 am

The long-term use of the so-called glitizones, a popular class of diabetes pills that includes Takeda’s Actos, drugs doubles the risk of bone fractures in women with type 2 diabetes, according to a study in the Canadian Medical Association Journal.

The study reviewed 10 previous clinical trials, and for every 20 women in their 70s with type 2 diabetes who took the drugs for at least one year, one has a chance of suffering a fracture. In women in their mid-50s, the figure equals one fracture in every 55 women. That’s more than double the normal risk for those age groups.


http://www.pharmalot.com/2008/12/avandia-actos-and-bone-fractures-in-women
 




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Diabetes drugs double women's fracture risk
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By Mary Brophy Marcus, USA TODAY

Long-term use of a popular class of oral diabetes drugs doubles the risk of bone fractures in women with type 2 diabetes, a new study reports.

According to researchers at Wake Forest University School of Medicine who reviewed 10 previous drug trials, for every 20 women in their 70s with type 2 diabetes who took thiazolidinediones — rosiglitgizone (brand name Avandia) and pioglitazone (brand name Actos) — for at least one year, one of them has a chance of suffering a fracture. In women in their mid-50s, the figure equals one fracture in every 55 women. That's more than double the normal risk for those age groups.

The new research appears online in the Canadian Medical Association Journal this week. About 14,000 patients were involved in the studies analyzed by study co-author Sonal Singh, assistant professor of internal medicine at Wake Forest, and his colleagues.

The same increase in fractures was not found in men, says Singh, though the reason why was not determined.

"You always weigh the good effects and the not-so-good effects," says study co-author Curt Furberg, professor of public health sciences at Wake Forest.

He points out that researchers now know that the drugs increase the risk of heart failure and the risk of fractures in women. The Food and Drug Administration last year ordered black box warnings on both drugs' labels against their use in patients with advanced congestive heart failure. Avandia has been shown to increase the risk of heart attacks as well.

"So it's very much a gamble to take the drugs," Furberg says.


http://www.usatoday.com/news/health/2008-12-09-diabetes-actos-avandia_N.htm