Grünenthal is Proving Itself in Pain
The need for abuse resistant tamper-resistant formulations is making good use of Grünenthal's technology which is being licensed out, but not yet FDA approved - to Endo Pharmaceuticals Inc. for use with a long-acting version of that company's pain drug OpanaER (oxymorphone) and Johnson & Johnson for TapentadolER.
In February 2009, Endo paid $28.5 million upfront to Grünenthal and committed about three times as much again in milestones for U.S. and Canadian rights to Phase II axomadol for moderate-to-severe chronic pain and diabetic peripheral neuropathy.
And in December 2010, Forest licensed U.S. and Canadian rights to a Phase II liquid formulation of morphine from Grünenthal, along with a pre-clinical follow-on, for $66.1 million upfront. Both compounds are opioid receptor-like-1/mu opioid agonists. Hitting both these receptors has been shown to produce a synergistic pain-relieving effect.
Grünenthal also has a non-narcotic opioid compound that should reach proof-of-concept by 2012, according to Stock.
J&J faces thalidomide boycott due to Ties with Grünenthal
By Andrew Jack, London Published: Feb 27 2011 20:28
Johnson & Johnson, the US healthcare company, faces the threat of a consumer boycott from campaigners who suffered birth defects 50 years ago caused by the morning sickness drug thalidomide created by Grünenthal.
Nick Dobrik, a member of the national advisory council to the UK’s Thalidomide Trust, said he was preparing a boycott and demonstrations against J&J in escalating efforts to seek compensation from Grünenthal, the German manufacturer of the drug, with which the US group has strong US commercial links.
The action is the latest effort by “thalidomiders” from the UK, Canada and Scandinavia to seek significant funding from Grünenthal, which was recently sued in Australia.
It would prove a fresh embarrassment to J&J, which is already suffering US congressional scrutiny. Its image has also been under attack over the past year following recalls, triggered by manufacturing problems identified by US regulators, of several top-selling consumer brands.
In 2006 J&J agreed joint development and commercialisation of Grünenthal’s tapentadol (Nucynta), a painkiller on sale since 2009. Grünenthal has argued that it followed the regulations for drug testing in force at the time, withdrawing thalidomide after the side-effects were identified. It paid compensation to those in Germany, leaving its foreign licence holders to defend against litigation elsewhere.
“We have expressed at several occasions that it is a matter of moral importance to Grünenthal to be actively involved in charitable efforts to improve the situation of thalidomide victims on a sustainable basis,” the company said. “It is of moral importance to us to seek to work together with thalidomide victims to devise projects for the provision of specific needs-based support.”
Mr Dobrik, who has escalated his campaigning after saying Grünenthal has launched a website called “stop the tears” – a reference to J&J’s “no more tears” slogan for baby products. “The fact that Grünenthal has still not provided any financial assistance to UK thalidomiders sums up the attitude of the pharma industry,” he said.
Copyright The Financial Times Limited 2011