Having worked in pharmaceuticals nearly 20 years although briefly with Shire - by far this company by my standards has an excellent reputation and products having promoted over two dozen successful drugs over two decades. In the pharma industry 'your manager can make you or break you' is a phrase I learned to follow - having been thru over a dozen managers, I have been fortunate to work with a majority of positive motivators as managers. At Shire, I have worked for two and both have been and are excellent people; yet I have heard and observed several who I would have dreaded to work for, and I feel sorry for those currently in that position because they do exist and even though you are successful, they continue to enforce a negative environment. When my manager comes to work with me, we have fun, we learn, and try to grow the business from our interactions, however the result is a positive experience I look forward to every month - few in this industry can say that!