Anonymous
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Anonymous
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You people are pathetic. I hope none of you morons are in my region. Get a life assholes!p
Mind your own business moron
You people are pathetic. I hope none of you morons are in my region. Get a life assholes!p
Wow you both should settle down. I'll make this clear for those of you who apparently know nothing about the sleep market. Silenor works through antihistaminergic pathways so it doesn't have the same sedative effects as GABA agonists (ambien/CR, Lunesta, halcion, etc) and has such extremely limited abuse potential that it is non-scheduled. The drawback is that at the doses that were approved it is barely effective for its indication and as you increase the dose to gain better efficacy, side effects that even the GABA agonists don't have start to appear. Thus if you are a physician you have to decide if you want your patient to pay for a dose that might not work in return for a reduction of side effects that doxepin (Silenor generic molecule) has at even 10mg. All the data available suggests that the efficacy for doxepin in promoting sleep and sleep maintenance is weak at best at the doses that Silenor is sold at. Additionally, Silenor does have an elderly indication but it still causes sedative effects that could cause injury in patients so I wouldn't champion it on that fact.
The point is that most patients could do just fine through the middle of the night on a generic ambien or trazodone when dosed low enough without too much of a safety issue. Those that don't respond can try the 1mg or 2mg dose of Lunesta or a whole host of older meds that provide some sedation at low doses. Problems occur when physicians don't keep patients in check on their dose or develop tolerance to a low dose. Silenor offers a potential benefit for only a small niche of patients who have had dependance or tolerance issues and should never be a "first line" start for any patient given its cost issues.
Get back to the fact that Silenor is an ultra-niche product that few physicians will even consider and really offers little benefit to patients. Have your drama queen battles here on cafepharma all you want to while those of us who practice medicine actually try to look out for our patients from all vantage points.
Oh its the voice of reason!!! Shut the fuck up you moron. We don t need your stupid explanation, we know this. My advice to you is to get back under the fucking rock your came from!!!!!!!!
Get the fuck out!!!!!!!!!!!!!!!!!1
Wow you both should settle down. I'll make this clear for those of you who apparently know nothing about the sleep market. Silenor works through antihistaminergic pathways so it doesn't have the same sedative effects as GABA agonists (ambien/CR, Lunesta, halcion, etc) and has such extremely limited abuse potential that it is non-scheduled. The drawback is that at the doses that were approved it is barely effective for its indication and as you increase the dose to gain better efficacy, side effects that even the GABA agonists don't have start to appear. Thus if you are a physician you have to decide if you want your patient to pay for a dose that might not work in return for a reduction of side effects that doxepin (Silenor generic molecule) has at even 10mg. All the data available suggests that the efficacy for doxepin in promoting sleep and sleep maintenance is weak at best at the doses that Silenor is sold at. Additionally, Silenor does have an elderly indication but it still causes sedative effects that could cause injury in patients so I wouldn't champion it on that fact.
The point is that most patients could do just fine through the middle of the night on a generic ambien or trazodone when dosed low enough without too much of a safety issue. Those that don't respond can try the 1mg or 2mg dose of Lunesta or a whole host of older meds that provide some sedation at low doses. Problems occur when physicians don't keep patients in check on their dose or develop tolerance to a low dose. Silenor offers a potential benefit for only a small niche of patients who have had dependance or tolerance issues and should never be a "first line" start for any patient given its cost issues.
Get back to the fact that Silenor is an ultra-niche product that few physicians will even consider and really offers little benefit to patients. Have your drama queen battles here on cafepharma all you want to while those of us who practice medicine actually try to look out for our patients from all vantage points.
I hope you are not a rep for our company. If you are , I know where to look in the rankings, LAST!!!!!! A "small niche of patients""" is that the way you sell???????????? you are a fucking moron and a SHIT REP. You have already lost even before you showed up on the field. go sell for Lunesta in my territory so I can crush you. Loser
And yet we have people calling the critizem of this post' Crazy" no the crazy people are the reps who agree with this traitor. Get fired quickly loser
Wow you both should settle down. I'll make this clear for those of you who apparently know nothing about the sleep market. Silenor works through antihistaminergic pathways so it doesn't have the same sedative effects as GABA agonists (ambien/CR, Lunesta, halcion, etc) and has such extremely limited abuse potential that it is non-scheduled. The drawback is that at the doses that were approved it is barely effective for its indication and as you increase the dose to gain better efficacy, side effects that even the GABA agonists don't have start to appear. Thus if you are a physician you have to decide if you want your patient to pay for a dose that might not work in return for a reduction of side effects that doxepin (Silenor generic molecule) has at even 10mg. All the data available suggests that the efficacy for doxepin in promoting sleep and sleep maintenance is weak at best at the doses that Silenor is sold at. Additionally, Silenor does have an elderly indication but it still causes sedative effects that could cause injury in patients so I wouldn't champion it on that fact.
The point is that most patients could do just fine through the middle of the night on a generic ambien or trazodone when dosed low enough without too much of a safety issue. Those that don't respond can try the 1mg or 2mg dose of Lunesta or a whole host of older meds that provide some sedation at low doses. Problems occur when physicians don't keep patients in check on their dose or develop tolerance to a low dose. Silenor offers a potential benefit for only a small niche of patients who have had dependance or tolerance issues and should never be a "first line" start for any patient given its cost issues.
Get back to the fact that Silenor is an ultra-niche product that few physicians will even consider and really offers little benefit to patients. Have your drama queen battles here on cafepharma all you want to while those of us who practice medicine actually try to look out for our patients from all vantage points.
Of course they are using the generics idiot, that is why they pay us good money to go in and break the mindless habits that docs are into these days. They call this SELLING!!!
You are a prime example of what is wrong with this industry. What a complete moron!!!!
Really a shame when someone speaks the truth and you get this type of reaction from some crazy person! I would like to thank the"voice of reason" for taking the time to properly inform us of what Silenor is all about.As for "crazy person"go back under the rock that YOU'VE BEEN UNDER!!
Great post!!!!!
REally???/ your agreeing with someone who says our drug is a niche drug to use when others fail. What a moron you are and a loser
REally???/ your agreeing with someone who says our drug is a niche drug to use when others fail. What a moron you are and a loser
To the post of the voice of reason: Fuck you asshole. Thanks for the stupid explaination
Can't expect you to understand a post that really was insightful and intelligent,because you are neither of those.The person that posted obviously has sold in the sleep market and understands the market and you obviously don't and that is why you are a joke and a failure!
Wow you both should settle down. I'll make this clear for those of you who apparently know nothing about the sleep market. Silenor works through antihistaminergic pathways so it doesn't have the same sedative effects as GABA agonists (ambien/CR, Lunesta, halcion, etc) and has such extremely limited abuse potential that it is non-scheduled. The drawback is that at the doses that were approved it is barely effective for its indication and as you increase the dose to gain better efficacy, side effects that even the GABA agonists don't have start to appear. Thus if you are a physician you have to decide if you want your patient to pay for a dose that might not work in return for a reduction of side effects that doxepin (Silenor generic molecule) has at even 10mg. All the data available suggests that the efficacy for doxepin in promoting sleep and sleep maintenance is weak at best at the doses that Silenor is sold at. Additionally, Silenor does have an elderly indication but it still causes sedative effects that could cause injury in patients so I wouldn't champion it on that fact.
The point is that most patients could do just fine through the middle of the night on a generic ambien or trazodone when dosed low enough without too much of a safety issue. Those that don't respond can try the 1mg or 2mg dose of Lunesta or a whole host of older meds that provide some sedation at low doses. Problems occur when physicians don't keep patients in check on their dose or develop tolerance to a low dose. Silenor offers a potential benefit for only a small niche of patients who have had dependance or tolerance issues and should never be a "first line" start for any patient given its cost issues.
Get back to the fact that Silenor is an ultra-niche product that few physicians will even consider and really offers little benefit to patients. Have your drama queen battles here on cafepharma all you want to while those of us who practice medicine actually try to look out for our patients from all vantage points.
I am a M and i want to clarify this for all you reps. First, i would fire any rep who had this attitude. you are not going to gain new business if you agree with this-this is why we PAY YOU, TO CHANGE THEIR OPINION!!! So that they DO NOT THINK LIKE THE AUTHOR OF THIS POST THINKS!!!!!!
I am very disapponted to see that many of our reps AGREE with the poster. Also , watch the foul language!!
I am a M and i want to clarify this for all you reps. First, i would fire any rep who had this attitude. you are not going to gain new business if you agree with this-this is why we PAY YOU, TO CHANGE THEIR OPINION!!! So that they DO NOT THINK LIKE THE AUTHOR OF THIS POST THINKS!!!!!!
I am very disapponted to see that many of our reps AGREE with the poster. Also , watch the foul language!!
So if you were the patient,you would want the doctor to bypass an effective low-cost generic(Ambien,etc) and Lunesta which has good MC coverage meaning lower co-pay,and go straight to a higher priced,low access,me-too of a generic,like Silenor.Anyone that would say yes to this is a fool,but Mr.DM I'm sure you would say yes to this scenario if you were the patient,right?Pompous Asshole!
I am a M and i want to clarify this for all you reps. First, i would fire any rep who had this attitude. you are not going to gain new business if you agree with this-this is why we PAY YOU, TO CHANGE THEIR OPINION!!! So that they DO NOT THINK LIKE THE AUTHOR OF THIS POST THINKS!!!!!!
I am very disapponted to see that many of our reps AGREE with the poster. Also , watch the foul language!!