bimekizumab is for psoriasis, different disease state and indication
Tapinarof initial indication is for psoriasis, AD is later and data no where near as convincing as rux cream
Roflumilast is a pde-4 like eucrisa and first indication will be psoriasis and again, data is not as strong for AD compared to rux cream
Oral JAKs are for moderate to severe AD and will carry a black box so will have bigger hurdles to overcome imo
Rux Cream is the only topical JAK that will hot market in next 1-2 years so great opportunity for 1st move like dupilumab.
Biologics for AD won’t be direct competitors for rux cream
Based on you citing agents that aren’t even indicated for AD, my gut tells me you don’t work here but are just looking to stir shit up on this thread.
The biggest hurdle for rux cream will be access, but without any other topical JAKs on market for at least 1-2 years, this will be Incyte’s blunder if it’s not a blockbuster. so please, continue to go on.