Amyvid!

[Anonymous]

Halfwit the treatment for misdiagnosis of dementia is still Aricept or Namenda- do you know anything about that disease state? Do you talk to your Dr.'s? Obviously not. Probably no access...

Quarterwit, the treatment for the misdiagnosis of Alzheimer's is the right diagnosis of whatever it is you have and the corresponding right treatment- ex. synthroid, multi-vitamin, anti-depressant, Lipitor, Plavix, shunt or levodopa. If it were your mom, then you would want the right diagnosis.

 

[Anonymous]

Quarterwit, the treatment for the misdiagnosis of Alzheimer's is the right diagnosis of whatever it is you have and the corresponding right treatment- ex. synthroid, multi-vitamin, anti-depressant, Lipitor, Plavix, shunt or levodopa. If it were your mom, then you would want the right diagnosis.

Sometimes, there are multiple factors at work. Maybe always. Strokes, neurotoxicity (maybe due to prescription drugs), other vascular conditions, diabetes, and many many more.

You can't really dumb this down too much. It's like cancer: not one disease, many.

 

[Anonymous]

Quarterwit, the treatment for the misdiagnosis of Alzheimer's is the right diagnosis of whatever it is you have and the corresponding right treatment- ex. synthroid, multi-vitamin, anti-depressant, Lipitor, Plavix, shunt or levodopa. If it were your mom, then you would want the right diagnosis.

Of course people will want the right diagnosis but like the previous poster said it doesn't change the treatment. And not to many people are going to pay out of pocket for a PET scan that they don't really need. Insurance will never cover this test.

 

[Anonymous]

Of course people will want the right diagnosis but like the previous poster said it doesn't change the treatment. And not to many people are going to pay out of pocket for a PET scan that they don't really need. Insurance will never cover this test.

Please tell me you are not saying Aricept and Synthroid are the same treatment. Do you think Namenda is going to correct my vitamin deficiency? Will the Exelon patch cure my depression? Is Cognex going to keep my grandma from having another stroke?

Y'all are missing a few cards in your deck.

 

[Anonymous]

Please tell me you are not saying Aricept and Synthroid are the same treatment. Do you think Namenda is going to correct my vitamin deficiency? Will the Exelon patch cure my depression? Is Cognex going to keep my grandma from having another stroke?

Y'all are missing a few cards in your deck.

What are you talking about Hick?

 

[Anonymous]

Of course people will want the right diagnosis but like the previous poster said it doesn't change the treatment. And not to many people are going to pay out of pocket for a PET scan that they don't really need. Insurance will never cover this test.

I believe the right (or more confident) diagnosis WILL change management. Many PCPs who are faced with a patient who presents with atypical symptoms today are either extremely cautious and delay initiation of treatment irrespective of the possible diagnosis, or take the other extreme approach and just stick patients onto drug therapy to see if the patient responds positively. Many PCPs faced with an atypical presentation spend a lot of time and effort in differential diagnosis over months and years already.

In future, with the opportunity to assess amyloid status early on, I think PCPs in particular will change the way they manage their trickier to diagnose patients. They will intervene earlier, come to a differential diagnosis earlier, counsel patients and their caregivers earlier and more confidently. They may be less likely to refer patients for further evaluation. Drug intervention is only one part of what one can do for the patient and caregiver and earlier initiation of a treatment plan has been shown to be more effective in symptomatic management, especially in early onset of dementia-like symptoms.

I think dementia experts will also change but maybe not as much. A challenge will be in encouraging experts to accept that they make mistakes and could do with help...

Definitely Amyvid is a leap of faith, but FFS what are we if we don't invest in new ways of managing these kinds of diseases. If you don't want to be part of this kind of thing why not move to selling generics or me-toos. No shame in it, far less risky (sort of)

 

[Anonymous]

What are you talking about Hick?

I think s/he's referring to all those patients who present with symptoms consistent with dementia who actually have Vitamin B12 or Vitamin D deficiency, geriatric depression or cerebrovascular disease. There are more potential causes of dementia misdiagnosis (let alone AD) than just being born in Bloomington, IN, but these are the main ones.

 

[Anonymous]

Halfwit the treatment for misdiagnosis of dementia is still Aricept or Namenda- do you know anything about that disease state? Do you talk to your Dr.'s? Obviously not. Probably no access...

There are rare posts when the poster writes their own built-in rebuttal. Bliss when it happens.

 

[Anonymous]

I believe the right (or more confident) diagnosis WILL change management. Many PCPs who are faced with a patient who presents with atypical symptoms today are either extremely cautious and delay initiation of treatment irrespective of the possible diagnosis, or take the other extreme approach and just stick patients onto drug therapy to see if the patient responds positively. Many PCPs faced with an atypical presentation spend a lot of time and effort in differential diagnosis over months and years already.

In future, with the opportunity to assess amyloid status early on, I think PCPs in particular will change the way they manage their trickier to diagnose patients. They will intervene earlier, come to a differential diagnosis earlier, counsel patients and their caregivers earlier and more confidently. They may be less likely to refer patients for further evaluation. Drug intervention is only one part of what one can do for the patient and caregiver and earlier initiation of a treatment plan has been shown to be more effective in symptomatic management, especially in early onset of dementia-like symptoms.

I think dementia experts will also change but maybe not as much. A challenge will be in encouraging experts to accept that they make mistakes and could do with help...

Definitely Amyvid is a leap of faith, but FFS what are we if we don't invest in new ways of managing these kinds of diseases. If you don't want to be part of this kind of thing why not move to selling generics or me-toos. No shame in it, far less risky (sort of)

I think, I think, I think....! You sure think a lot a have some very strong opinions. This is typical Lilly. In the end, it matters what the physicians think and do and what you think does not make a damn bit of difference.
The arrogance of Lilly people, especially brand people, is enough to choke an elephant.

 

[Anonymous]

I think, I think, I think....! You sure think a lot a have some very strong opinions. This is typical Lilly. In the end, it matters what the physicians think and do and what you think does not make a damn bit of difference.
The arrogance of Lilly people, especially brand people, is enough to choke an elephant.

I think you're an idiot and your post makes no sense.

 

[Anonymous]

I think you're an idiot and your post makes no sense.

The post would obviously make no sense to a self centered little brat stuck in his/her own little world.

 

[Anonymous]

I believe the right (or more confident) diagnosis WILL change management. Many PCPs who are faced with a patient who presents with atypical symptoms today are either extremely cautious and delay initiation of treatment irrespective of the possible diagnosis, or take the other extreme approach and just stick patients onto drug therapy to see if the patient responds positively. Many PCPs faced with an atypical presentation spend a lot of time and effort in differential diagnosis over months and years already.

In future, with the opportunity to assess amyloid status early on, I think PCPs in particular will change the way they manage their trickier to diagnose patients. They will intervene earlier, come to a differential diagnosis earlier, counsel patients and their caregivers earlier and more confidently. They may be less likely to refer patients for further evaluation. Drug intervention is only one part of what one can do for the patient and caregiver and earlier initiation of a treatment plan has been shown to be more effective in symptomatic management, especially in early onset of dementia-like symptoms.

I think dementia experts will also change but maybe not as much. A challenge will be in encouraging experts to accept that they make mistakes and could do with help...

Definitely Amyvid is a leap of faith, but FFS what are we if we don't invest in new ways of managing these kinds of diseases. If you don't want to be part of this kind of thing why not move to selling generics or me-toos. No shame in it, far less risky (sort of)

What you are failing to also point out is that an ASL-MRI can tell the exact same thing and costs 4 times less...Amyvid is never going to be covered by Medicare. Its just not needed and PET scans are way to expensive to be used regularly.

http://www.sciencedaily.com/releases/2011/11/111116162238.htm

 

[Anonymous]

What you are failing to also point out is that an ASL-MRI can tell the exact same thing and costs 4 times less...Amyvid is never going to be covered by Medicare. Its just not needed and PET scans are way to expensive to be used regularly.

http://www.sciencedaily.com/releases/2011/11/111116162238.htm

Arterial Spin Labeling (ASL) MRI is an alternative way of measuring cerebral blood flow.

I am confused that you state that it "can tell the exact same thing" as Amyvid. It does not measure or indicate the presence of amyloid plaques. Do you mean it can give the same contribution to accurate differential diagnosis of AD? If so, do you have sensitivity and specificity versus autopsy? Just wondering...

ASL-MR imaging's usefulness in alzheimer's research is limited to studying the connection between hypertension and blood flow patterns in clinically diagnosed subjects. There are other tracers which can image CBF which are even cheaper than MR but good luck in reading and interpreting them reliably.

It is very useful and interesting data but not a diagnostic tool.

 

[Anonymous]

I think, I think, I think....! You sure think a lot a have some very strong opinions. This is typical Lilly. In the end, it matters what the physicians think and do and what you think does not make a damn bit of difference.
The arrogance of Lilly people, especially brand people, is enough to choke an elephant.

Good point. Too much thinkin', too many opinions. What is this place? A discussion board or... oh wait...

 

[Anonymous]

What you are failing to also point out is that an ASL-MRI can tell the exact same thing and costs 4 times less...Amyvid is never going to be covered by Medicare. Its just not needed and PET scans are way to expensive to be used regularly.

http://www.sciencedaily.com/releases/2011/11/111116162238.htm

Hey dumbass, did you actually read the article in your link?? It compares MRI to FDG-PET. Not the same as Amyvid-PET. Jeez, moron. Don't fake your expertise.

 

[Anonymous]

Hey dumbass, did you actually read the article in your link?? It compares MRI to FDG-PET. Not the same as Amyvid-PET. Jeez, moron. Don't fake your expertise.

MRI's are way less expensive then a PET scan...

I hope Amyvid does well but the odds are stacked against it!

 

[Anonymous]

MRI's are way less expensive then a PET scan...

I hope Amyvid does well but the odds are stacked against it!

Odds are against Amyvid, I agree. Maybe the reality is that we shouldnt see this like a screening tool, when actually it is only for the tricky patients who can't be diagnosed in one visit.
my Mom had multiple tests including a mental state exam over about 4 months and two years later, the doc seems reluctant to say outright that she has Alzheimer's. I wouldn't mind knowing myself what her prognosis is, but I get told she may have Lewy bodies which can be a more rapid decline and have a different prognosis and symptoms. Or she may have both, god forbid.
I don't see this test as a final answer but I can see medical care being guided by the info it provides. I just have to think about whether I'd pay for it and the answer now is no, unless the doc says he could use the info. I think I would have paid for it if it had been around 2 years ago though!

Your perspective about a disease changes massively when it comes close to home.

 

[Anonymous]

Odds are against Amyvid, I agree. Maybe the reality is that we shouldnt see this like a screening tool, when actually it is only for the tricky patients who can't be diagnosed in one visit.
my Mom had multiple tests including a mental state exam over about 4 months and two years later, the doc seems reluctant to say outright that she has Alzheimer's. I wouldn't mind knowing myself what her prognosis is, but I get told she may have Lewy bodies which can be a more rapid decline and have a different prognosis and symptoms. Or she may have both, god forbid.
I don't see this test as a final answer but I can see medical care being guided by the info it provides. I just have to think about whether I'd pay for it and the answer now is no, unless the doc says he could use the info. I think I would have paid for it if it had been around 2 years ago though!

Your perspective about a disease changes massively when it comes close to home.

Why would you have paid for the test two years ago and not today? I enjoyed reading your post and hearing your perspective.

 

[Anonymous]

Good point. Too much thinkin', too many opinions. What is this place? A discussion board or... oh wait...

Choking the Elephant is their pleasure and their reason to exist.

 

[Anonymous]

Odds are against Amyvid, I agree. Maybe the reality is that we shouldnt see this like a screening tool, when actually it is only for the tricky patients who can't be diagnosed in one visit.
my Mom had multiple tests including a mental state exam over about 4 months and two years later, the doc seems reluctant to say outright that she has Alzheimer's. I wouldn't mind knowing myself what her prognosis is, but I get told she may have Lewy bodies which can be a more rapid decline and have a different prognosis and symptoms. Or she may have both, god forbid.
I don't see this test as a final answer but I can see medical care being guided by the info it provides. I just have to think about whether I'd pay for it and the answer now is no, unless the doc says he could use the info. I think I would have paid for it if it had been around 2 years ago though!

Your perspective about a disease changes massively when it comes close to home.

Try giving her Picamilon. It's niacin and GABA linked together. Improves both blood circulation in the brain, plus eases the anxiety.... M.D.