TauRx’s HMTM could be the first anti-tau disease-modifying drug for Alzheimer’s

On 6 October TauRx announced topline results from its Phase III LUCIDITY trial (NCT03446001) evaluating its oral anti-tau product, hydromethylthionine mesylate (HMTM), in patients with early, mild, and moderate Alzheimer’s disease (AD). In patients with early AD, HMTM treatment resulted in sustained improvement in cognition compared with the pre-treatment baseline measured using the Alzheimer’s Disease Assessment Scale–Cognitive subscale (ADAS-cog13 scale). In patients with mild to moderate AD, HMTM stabilised cognition and function. Additionally, HMTM treatment reduced the rates of brain atrophy when compared with historical matched patients with AD.