Roche halts enrollment in a PhII combo study of Tecentriq and Cotellic in wake of several patient deaths

A string of deaths in a cohort of colon cancer patients taking a combination of Roche’s PD-L1 checkpoint Tecentriq with Exelixis’ MEK inhibitor Cotellic forced the independent monitoring board to halt enrollment of new patients in their Phase II MODUL study. And Roche says one of those deaths was a treatment-related case of cardiotoxicity.