REGN5459 Delivers Dose-Dependent Responses in Relapsed/Refractory Myeloma

The BCMA- and CD3-directed bispecific antibody REGN5459 led to fast onset, deep, and dose-dependent responses sustained over time, with a high frequency of manageable low-grade cytokine release syndrome (CRS) in patients with relapsed/refractory multiple myeloma, according to findings from a first-in-human phase 1/2 trial (NCT04083534) that were presented at the 2023 AACR Annual Meeting.1,2