Pressing the pause button on CAR-T cells with Bristol-Myers’ leukemia drug

Scientists at the University Hospital Würzburg showed that Sprycel can act quickly to put a temporary pause on CAR-T cells in mice, sparing some of the animals from the potentially fatal CRS. The findings, published in the journal Science Translational Medicine, suggest the drug could be used as an “on/off switch” for CAR-T cells, they say.