Lilly steps up its oral obesity push

Mounjaro might be approaching the finish line in obesity, but Lilly is wasting no time in pushing forward its follow-on projects. Two new trials of its oral GLP-1 contender, orforglipron (LY3502970), are now listed on CT.gov, joining the open-label Achieve-4, which began recruiting in April. Only very top-line phase 2 data on orforglipron have been released so far, and Lilly has admitted that the agent is unlikely to promote as much weight loss as Mounjaro, which hits GIP as well as GLP-1.