ESMO: Exelixis lays out promising early Cabometyx combo data in prostate cancer, but key discrepancies persist

In Exelixis’ phase 1b COSMIC-021 trial, its tyrosine kinase inhibitor Cabometyx coupled with Roche’s immuno-oncology med Tecentriq demonstrated a clinically meaningful result in a cohort of patients with metastatic castrate-resistant prostate cancer (mCRPC) who were previously treated with Pfizer and Astellas’ Xtandi (enzalutamide) or Johnson & Johnson’s Zytiga (abiraterone acetate), according to details shared at the European Society for Medical Oncology annual congress.