Endo's frozen shoulder plan comes unstuck, with phase 2 flop driving strategy reevaluation

Endo International’s attempt to use ultrasound-guided injection of collagenase clostridium histolyticum (CCH) to treat frozen shoulder has come unstuck. The drug, the active ingredient in the approved Xiaflex, failed to beat placebo in a phase 2 clinical trial, driving Endo to reevaluate its plans in the indication.