CTAD 2022 – gantenerumab’s shortcomings keep amyloid hypothesis alive

While Biogen was moved to reanalyse two failed pivotal studies and cherrypick data from one to back the controversial approval of Aduhelm, its competitor Roche proceeded rather differently. The Swiss group took under three weeks to decide that the Graduate 1 and 2 trials warranted shutting down its gantenerumab programme entirely, CTAD heard last night.