Bristol-Myers star Opdivo fails survival test in a matchup with Nexavar aimed at shaking up the big HCC market

Bristol-Myers Squibb has suffered another painful setback in its years-long quest to expand the reach of Opdivo. The pharma giant this morning noted that their Checkmate-459 study comparing Opdivo with Bayer’s Nexavar in frontline cases of hepatocellular carcinoma — the most common form of liver cancer — failed to hit the primary endpoint on overall survival.