ASH: Senti Bio's gene circuit CAR-NK cell therapy enhances cancer killing and safety in leukemia models

Engineered cell therapy has revolutionized the treatment of blood cancers, but precisely selecting the right target to kill off cancer cells while sparing healthy cells has been challenging for some disease types. Now, Senti Bio has promising early data that a CAR-NK (natural killer) cell therapy developed from the biotech’s gene circuit platform could solve that problem—and provide an off-the-shelf option—in acute myeloid leukemia (AML).