Antipsychotic from Lundbeck, Otsuka flops again in PhIII trials — this time in bipolar patients

New Lundbeck CEO Deborah Dunsire has more bad news to contend with, five months into her appointment. The Danish drugmaker — which is battling with generics eating into sales of three key drugs and a recent setback for schizophrenia — on Thursday said a pair of pivotal trials failed to show its blockbuster antipsychotic drug, brexpiprazole, helped patients with bipolar disorder.