The 25 Most Popular Drugs by U.S. Spending

The United States spent a total of more than $722 billion on prescription drugs in 2023, a new report finds. That’s a nearly 14 percent increase in spending from 2022 — the largest annual rise in the last 20 years — and researchers say that growth is only expected to continue in 2024. 

Prescription medications for diabetes, weight loss, arthritis, blood clots topped the list in 2023.