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WSJ: Scientist's lawsuit accuses AstraZeneca of fudging Brilinta study

NBRx hasn't increased since October and then it was only short lived. Prior to that it was flat for 6 months. They put sales leaders in charge that did not even have good success as RSDs. What do you expect? Different results? They have run out of excuses. They hired nurses, IDs, more reps, RSDs, clinical people. They can't keep throwing good money after bad. It's only a matter of time before leadership pulls the plug. The drug is costing us way more than it will ever bring in, unfortunately.

The question is could AZ save face by pulling Brilinta, or cutting the sales force back and allowing it to wither like Sular, Ropivacaine, or Accolate. At what point do you recognize failure, and what do you think would be the time line? It seems that three years would be a long time and two have already passed.

On the other side of the coin Seroquel and Crestor had slow starts but eventually ramped up. Does Brilinta still have a shot or is it down for the count?
 








Why would all Pharma be doomed - unless not playing by the rules? Any suspect trials should not pass validation. These are chemicals, generally with both beneficial and harmful effects that people put into their bodies, in good faith that the compound has proven safety and efficacy in a well regulated and legitimate environment - as it should be.
 




The question is could AZ save face by pulling Brilinta, or cutting the sales force back and allowing it to wither like Sular, Ropivacaine, or Accolate. At what point do you recognize failure, and what do you think would be the time line? It seems that three years would be a long time and two have already passed.

On the other side of the coin Seroquel and Crestor had slow starts but eventually ramped up. Does Brilinta still have a shot or is it down for the count?
Seroquel and Crestor competed in very different markets than today's. There has been so much talk and focus on making Brilinta a megabrand by Pascal and top leadership, that they may lose some face if they were to cut back significantly. It will need to be a decision made within the next year regardless of the OIG investigation. Regardless, it will need to be a business decision. NBRx and at least 90 day adherence rates really need to take off soon. They will have a tough time with the sales leaders they have in place. Some may have learned the market, but they lack the ability to motivate and lead/work through the many obstacles in today's complex environment.
 




Seroquel and Crestor competed in very different markets than today's. There has been so much talk and focus on making Brilinta a megabrand by Pascal and top leadership, that they may lose some face if they were to cut back significantly. It will need to be a decision made within the next year regardless of the OIG investigation. Regardless, it will need to be a business decision. NBRx and at least 90 day adherence rates really need to take off soon. They will have a tough time with the sales leaders they have in place. Some may have learned the market, but they lack the ability to motivate and lead/work through the many obstacles in today's complex environment.
All you need to do is line up all of the brand team and sales leaders, RSD and above and have everyone sit down who has never been involved in leading a successful product launch in any capacity. How many would remain standing? Nuff said.
Like the song says, Oh where have you gone Joe Dimaggio? Our stars left a long time ago and all that remain are snot nosed Ivy Leaguers and brown nosers who worked their way up by politics and backstabbing.
 








Why would all Pharma be doomed - unless not playing by the rules? Any suspect trials should not pass validation. These are chemicals, generally with both beneficial and harmful effects that people put into their bodies, in good faith that the compound has proven safety and efficacy in a well regulated and legitimate environment - as it should be.

Because if true, I believe that the process itself in studying drugs on a global scale to be inherently flawed. It would throw into question ALL drug companies and ALL future trials basically putting the death nail in pharma's coffin. You think trust is bad now, just wait.
 




Seroquel and Crestor competed in very different markets than today's. There has been so much talk and focus on making Brilinta a megabrand by Pascal and top leadership, that they may lose some face if they were to cut back significantly. It will need to be a decision made within the next year regardless of the OIG investigation. Regardless, it will need to be a business decision. NBRx and at least 90 day adherence rates really need to take off soon. They will have a tough time with the sales leaders they have in place. Some may have learned the market, but they lack the ability to motivate and lead/work through the many obstacles in today's complex environment.

Pascal/AZ will never voluntarily withdraw Brilinta from the market. Only the DOJ could force their hand, but i am sure they have already been paid off. Brilinta, in a few months will have been out 3 years. 3 years! How long are they going to continue dumping good money after bad???
 




Pascal/AZ will never voluntarily withdraw Brilinta from the market. Only the DOJ could force their hand, but i am sure they have already been paid off. Brilinta, in a few months will have been out 3 years. 3 years! How long are they going to continue dumping good money after bad???

Maybe not a voluntary withdraw, but at some point any manager worth a salt does not continue to throw good money after bad and will scale back. I can't imagine that Pascal is that dumb.
 








Just step back and get real for a second, if possible:

Soirot got a check for over $1,000,000.00 before he took the job.

I could write more, but need I, really? For those of you who are not comprehensive: Why would any rational person try to enact change to the situation? Remember he has a guaranteed payment in case things go bad, as they surely will.

So he'll have an O'Bama speech and blame someone else, and immediately thereafter take a private jet to his island next to Dave Brennan's island and live the good life that he has extorted from the IDIOTS that are the AZ board. Face it.
 




This is the iceberg that is going to take AZ down and no spin can save it.
AZ has been in a death spiral for several years and yet most people are just like sheep being led to the slaughter just living from day to day as if they don't have a problem in the world. I laugh when I hear some young newbie talking about how their DM is encouraging them to look for a promotion or developmental position. I compare it to competing for band director on the Titanic.
 












So he'll have an O'Bama speech and blame someone else, and immediately thereafter take a private jet to his island next to Dave Brennan's island and live the good life that he has extorted from the IDIOTS that are the AZ board. Face it.[/QUOTE]

O'Bama? Hmm, didn't realize the President was IRISH. Dope.