Why is Lilly research so impotent?

[Anonymous]

Regarding the $6 billion acquisition of Imclone, as you said, the Erbitux revenues are modest and I suspect that unless ramucirumab pans out there is not much there in the way of new products. As far as AME 10 years later we have nothing to show for it other than a continual cash drain. For the money we have wasted we could have acquired real drugs.
By way of example, Abbott bought Humira (by acquiring Knoll for 7 billion) and now have 9 bilion dollar/year (!) drug. Amgen got Enbrel (by buying Immunex for 11 billion) which is doing about 5 billion/year now. By comparison the 400 million or so we are getting from Imclone is a puny return considering the original 6 billion dollar price tag.

Just my take

But the builiding in San Diego is SUPER-COOL--it's got solar-powered urinals!! Very low carbon footprint....with a very HIGH Ca$h burn.

 

[Anonymous]

Behold: I disclose unto you The FUTURE of R&D at LLY:

Good news! C&EN Jobs has found 4 new jobs that meet your criteria.

Scientific Leader, Medicinal Chemistry

Lilly China Research and Development Center - CHN - Shanghai - Mar-19-2013

Requirements: • Ph.D. in Organic Chemistry and/or Medicinal Chemistry Experience. • Minimum of 10 years experience in diabetes and/or cardiometabolic disease drug discovery efforts. • Proven...

- Read more and apply

Sr. Scientist, DMPK

Lilly China Research and Development Center - CHN - Shanghai - Mar-19-2013

KEY OBJECTIVES/DELIVERABLES: 1. Design and implement aggressive, innovative preclinical ADME plans for drug discovery projects. 2. As a subject matter expert, work with Drug Disposition colleagu...

- Read more and apply

Research Scientist, Preformulation

Lilly China Research and Development Center - CHN - Shanghai - Mar-19-2013

KEY OBJECTIVES/DELIVERABLES: Job Responsibilities 1. Provide preformulation support on pre-projects, projects and programs during the discovery phase. This includes program sanction and candidat...

- Read more and apply

Senior Scientist, Early Process Chemistry Development

Lilly China Research and Development Center - CHN - Shanghai - Mar-19-2013

Requirements: • Understanding of the drug discovery process & early process chemistry development. • Expertise in translating chemistry from small- to larger scale (mg’s to multi-grams to kilo ...

- Read more and apply

 

[Anonymous]

The future of LRL Research:

Good news! C&EN Jobs has found 4 new jobs that meet your criteria.
Scientific Leader, Medicinal Chemistry
Lilly China Research and Development Center - CHN - Shanghai - Mar-19-2013
Requirements: • Ph.D. in Organic Chemistry and/or Medicinal Chemistry Experience. • Minimum of 10 years experience in diabetes and/or cardiometabolic disease drug discovery efforts. • Proven...
Sr. Scientist, DMPK
Lilly China Research and Development Center - CHN - Shanghai - Mar-19-2013
KEY OBJECTIVES/DELIVERABLES: 1. Design and implement aggressive, innovative preclinical ADME plans for drug discovery projects. 2. As a subject matter expert, work with Drug Disposition colleagu...
Research Scientist, Preformulation
Lilly China Research and Development Center - CHN - Shanghai - Mar-19-2013
KEY OBJECTIVES/DELIVERABLES: Job Responsibilities 1. Provide preformulation support on pre-projects, projects and programs during the discovery phase. This includes program sanction and candidat...
Senior Scientist, Early Process Chemistry Development
Lilly China Research and Development Center - CHN - Shanghai - Mar-19-2013
Requirements: • Understanding of the drug discovery process & early process chemistry development. • Expertise in translating chemistry from small- to larger scale (mg’s to multi-grams to kilo ...

 

[Anonymous]

This is a serious question, not a cheap shot. Someone told me that the last drug to come out of the Lilly Research Labs was discovered in the 1980's (I think they said Zyprexa or Evista, but not sure). If that is true, why? You people seem smart enough, is it the structure of the organization? Management? What?

It may have been Evista but it wasn't Zyprexa. Zyperxa was a Sandoz product.

 

[Anonymous]

But the builiding in San Diego is SUPER-COOL--it's got solar-powered urinals!! Very low carbon footprint....with a very HIGH Ca$h burn.

I laughed when I read that comment...but it is really sad when you think about it. Lilly used to be (not that long ago actually) one of the two or three finest places for pharma research with novel, first in class molecules and a reputation second to none. Now we have what...some goofy site in San Diego just because it is trendy these days (as if it really mattered where you were located) and we buy into BS like "low carbon footprint" and "solar powered". I say close down SD, fire al the deadbeat losers and get back to REAL SCIENCE and things will work out just fine.

 

[Anonymous]

I laughed when I read that comment...but it is really sad when you think about it. Lilly used to be (not that long ago actually) one of the two or three finest places for pharma research with novel, first in class molecules and a reputation second to none. Now we have what...some goofy site in San Diego just because it is trendy these days (as if it really mattered where you were located) and we buy into BS like "low carbon footprint" and "solar powered". I say close down SD, fire al the deadbeat losers and get back to REAL SCIENCE and things will work out just fine.

When you have feckless, spineless dross like AP "running" chemistry, this is what you get. He gets to attend groundbreakings, and re-shuffle powerpoint decks.

 

[Anonymous]

It may have been Evista but it wasn't Zyprexa. Zyperxa was a Sandoz product.

Not true, Zyprexa (olanzepine) was invented at Erl Wood. Additionally, the Vertex HCV drug and the Pfizer HIV protease inhibitor were both products from Lilly internal discovery but were declined for the portfolio and returned to the respective partner (Vertex and Agouron) .

 

[Anonymous]

Why don't you accept that the patent protected portfolio is bullshit?

Why? Millions and billions of reasons.

Health care company? Kiss my ass, where the sun don't shine.

 

[Anonymous]

Not true, Zyprexa (olanzepine) was invented at Erl Wood. Additionally, the Vertex HCV drug and the Pfizer HIV protease inhibitor were both products from Lilly internal discovery but were declined for the portfolio and returned to the respective partner (Vertex and Agouron) .

The talented chemists (Steve K and ShuHui C) who invented those drugs bailed many moons ago .... and went on to achieve great things. They were smart enough to see the writing on the wall and the pathetic leadership within chemistry at Lilly

 

[Anonymous]

DCRT excellent at identifying SAR issues, excellent when it comes to making things, excellent when it comes to suggesting new SAR targets, sadly there is no single LRL chemist who occupies the middle of this 3-circle Venn Diagram. That's probably why they dont have the label medicinal chemist in the company...

 

[Anonymous]

DCRT excellent at identifying SAR issues, excellent when it comes to making things, excellent when it comes to suggesting new SAR targets, sadly there is no single LRL chemist who occupies the middle of this 3-circle Venn Diagram. That's probably why they dont have the label medicinal chemist in the company...

First, you have to have HR people managed correctly to be able to identify the breadth of talent necessary to do drug design.

They hear "diversity" and they try to make the place the UN.

 

[Anonymous]

DCRT excellent at identifying SAR issues, excellent when it comes to making things, excellent when it comes to suggesting new SAR targets, sadly there is no single LRL chemist who occupies the middle of this 3-circle Venn Diagram. That's probably why they dont have the label medicinal chemist in the company...

Because you must go through a gaunlet of imbeciles, whose sole function is to approve the font of your PowerPoint deck...and to let you know you haven't "..achieved results with people." Right Sandy?

 

[Anonymous]

First, you have to have HR people managed correctly to be able to identify the breadth of talent necessary to do drug design.

They hear "diversity" and they try to make the place the UN.

this was the beginning of the end here in sales as well...

Ol'Timer

 

[Anonymous]

Because you must go through a gaunlet of imbeciles, whose sole function is to approve the font of your PowerPoint deck...and to let you know you haven't "..achieved results with people." Right Sandy?

Good post. Working the past 10+ years in LRL that is pretty much the story. Endless time spent "selling" projects, programs to management. An enormous amount of time dedicated to making slides for various committees. The worst part is that the committees don't like to make decisions and very little is actually ever decided. Its all about politics and posturing. Most of the CSO/director level people spend their time in meetings, making and reviewing PowerPoint slides (yes, changing font!). BioTDR is notorious for this, the mangers are utter incompetents who are TB's lackeys. Cannot make a decision to save their lives. Could it be why BioTDR has not come up WITH A SINGLE DRUG IN 16 YEARS?

 

[Anonymous]

The PM system makes people really stupid.

Really.

I was there.

No matter how good your work, you WILL BE TOLD that you just don't get it.

It's all about nice castles in Carmel or the like, people in total denial about reality.

In today's reality, you really have to be focused upon POSITIVE outcomes, not 6 sigma BS

 

[Anonymous]

They eat Donkey Turds.

 

[anonymous]

Stock on a roll. Wall Street loves. Maybe it was better to gut research and bring in preclinical candidates from outside.
https://www.prnewswire.com/news-rel...program-from-hydra-biosciences-300765876.html

When you have feckless, spineless dross like AP "running" chemistry, this is what you get. He gets to attend groundbreakings, and re-shuffle powerpoint decks.