I have been on Linzess for a while. My dr. Increased my dosage to 290mg. Per day since after a while the lower dosage did not work for me. The same thing happened at the higher dose. (I am even taking Colace with it; sometimes 2 times a day. The Linzess only once. ) I do get diarrhea once or twice per day on the first couple of days but after that I am having to add more Colace or Miralax.
I was prescribed the "new drug", Trulance last month. The dr. even showed me how to go on line and get the discount ( $25 per prescription ), but the pharmacy told me that was for one time only and when I read the info on the website it said if you have insurance you won't receive the discount.
Anyway, I have taken Trulance for almost 3 weeks. No diarrhea!
In fact, when I do go, my stools are very hard. Plus I must take the stool softeners and Miralax in order to produce that. So, as a patient who has experienced both drugs, I prefer Linzess. If I don't "go", I must deal with gas, bloating, stomach cramps, and indigestion as well as the constipation.
I know this may seem like ,TMI, but I am reading all of your posts and not seeing any real patients weighing in on how your drugs are really working.
For me, neither are truly doing the job.
Just an FYI for you.