Time to let Prolia go

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Anonymous said:
And a damn good one at that! Oh BTW, tell your Prolia patients to NEVER skip a dose. We hate to see their fracture risk increase greater than pretreatment levels! It could get ugly.
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I know bmd return to baseline after discontinuation, but is it true that there is fracture risk associated? I would dare say that if that showed up in Phase 2 and 3 discontinuation trials, we would have heard it by now.
 












Reclast rep here-

You don't sell prolia because we don't want you to. All of the relationships and business have already been milked dry. The only reason Reclast reps are running for the hills is because Reclast goes generic in a year along with a 70% reduction in field force size. Here is a hint in the Rheums offices. They aren't writing your product because they suppress the immune systems of all their patients. Although your infection rates are small, severity increases in those patient types. Why not use a once a year medication with less risk, less money, and efficacy just as strong or stronger than prolia. By the way, your biochemical markers increase off of the chart as soon as one dose is missed. P.S. Are you guys hiring right now? I could really use a job after I get laid off.
 






King Mis-information. Typical of a Novartis representative. Please check your facts before you deride superior science. Prolia-Ctx markers return to baseline. None of the antibodies associated with denosumab have been found to be 'neutralizing', hence immunogenicity affect is miniscule, if apparent at all.
However, thanks for spreading your bullshirt. Gives us an opportunity to clarify...with scientifically proven outcomes. Reclast, like all bisphosphonates are chemical poisons. Efficacy, yes. Safety, no. Dirty, dirty, dirty medicine. I wouldn't put my mother on a bisphosphanate, let alone one so devastating to the kidney, as zoledronic acid is. PS- Have you actually read the 6 year Horizon extension trial? Or, as is typical with Novartis (ie, aliskeren) do your leaders choose to bury the truth until patients begin dropping like flies? Can anyone say 'Tekturna'?!
Prolia is the future of osteoporotic care. Seek out your Prolia counterpart and begin seeking employment. Education will set you free. Peace.
 






Kids...stop the bickering. The brand is projected to be a block buster. slow start due to poor sales rep, part D prior auth, and reimbursement issues.

Most of the country is finally starting to figure out what the heck they are doing. The goals are finally attainable for the nation. So if I have to put money on it, Prolia is here to stay. Unless there are major changes from the FDA.
 






Anonymous said:
King Mis-information. Typical of a Novartis representative. Please check your facts before you deride superior science. Prolia-Ctx markers return to baseline. None of the antibodies associated with denosumab have been found to be 'neutralizing', hence immunogenicity affect is miniscule, if apparent at all.
However, thanks for spreading your bullshirt. Gives us an opportunity to clarify...with scientifically proven outcomes. Reclast, like all bisphosphonates are chemical poisons. Efficacy, yes. Safety, no. Dirty, dirty, dirty medicine. I wouldn't put my mother on a bisphosphanate, let alone one so devastating to the kidney, as zoledronic acid is. PS- Have you actually read the 6 year Horizon extension trial? Or, as is typical with Novartis (ie, aliskeren) do your leaders choose to bury the truth until patients begin dropping like flies? Can anyone say 'Tekturna'?!
Prolia is the future of osteoporotic care. Seek out your Prolia counterpart and begin seeking employment. Education will set you free. Peace.
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Douche...you could at least tell some of the primary care docs that prolia is a biologic!!!
Rheums understand the class, but the GP's have no clue of side effects or safety info.
 






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