The beginning of the end of Rahway

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Merck divorcing Rahway speaks more to the impending failure of Merck than it does to any lack of performance of Rahway. If they cannot get value from Rahway they cannot get value from anything. Merck's corporate managers shown by means of their decisions to outsource anything they cannot comprehend, that they have insufficient understanding of this industry's basis. And that leadership skill set does not seem to getting any better. This formerly technically strong company is well on its way to being a mediocre virtual company. And its decline will not end until it becomes an ex-company. Merck's leaders used to be famously arrogant about their technology. Now they are only arrogant. Like it or not, technology is at the heart of what Merck needs to be all about. And Merck has proven that they are clueless about possessing it and directing it. Be very afraid.
 






Drugs from Rahway - Mevacor, Zocor, Emend, Januvia, Janumet to name a few and when Immunolgy was in Rahway they contributed to all of the vaccines. Drugs in the pipeline from Rahway - CETP inhibitor and all of the cardiovascular/hypertensive drugs are from Rahway. Several others are also in late stage developement that had their start in Rahway.

As an FYI - all of the hypertensive, anti-inflammatory drugs MRL ever produced were from Rahway. As a comparison - Boston: no drugs, and if you exclude anti-virals and vaccines, WP is also a big 0. Only site to match Rahway was MF, which had Vioxx and Singular.

And while MRL was building new labs in Boston and WP, the last Biology building was built in the early 80's in Rahway and most of the others dates from the 60s and 70s.
 












Anonymous said:
Drugs from Rahway - Mevacor, Zocor, Emend, Januvia, Janumet to name a few and when Immunolgy was in Rahway they contributed to all of the vaccines. Drugs in the pipeline from Rahway - CETP inhibitor and all of the cardiovascular/hypertensive drugs are from Rahway. Several others are also in late stage developement that had their start in Rahway.

As an FYI - all of the hypertensive, anti-inflammatory drugs MRL ever produced were from Rahway. As a comparison - Boston: no drugs, and if you exclude anti-virals and vaccines, WP is also a big 0. Only site to match Rahway was MF, which had Vioxx and Singular.

And while MRL was building new labs in Boston and WP, the last Biology building was built in the early 80's in Rahway and most of the others dates from the 60s and 70s.
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And WHY the guys closed MF if it was so successful?
 






All the drugs mentioned were discovered in Rahway. I am not sure why there is such a negative attitude towards Rahway. Let me shake up whatever area you are in a few times over the past 5 years and see how productive you would be.
 






Anonymous said:
Drugs from Rahway - Mevacor, Zocor, Emend, Januvia, Janumet to name a few and when Immunolgy was in Rahway they contributed to all of the vaccines. Drugs in the pipeline from Rahway - CETP inhibitor and all of the cardiovascular/hypertensive drugs are from Rahway. Several others are also in late stage developement that had their start in Rahway.

As an FYI - all of the hypertensive, anti-inflammatory drugs MRL ever produced were from Rahway. As a comparison - Boston: no drugs, and if you exclude anti-virals and vaccines, WP is also a big 0. Only site to match Rahway was MF, which had Vioxx and Singular.

And while MRL was building new labs in Boston and WP, the last Biology building was built in the early 80's in Rahway and most of the others dates from the 60s and 70s.
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Why would you exclude antivirals?
 


















Anonymous said:
Politics, pure and simple!

MF actually discovered Singulair, Vioxx, Arcoxia, Fosomax, Cordaptive.
WP nothing in 20 years!

Great business decisions. Politics will kill the company.
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Actually any decision to retain WP is consistent with the long-range business plan. The company wishes to develop and manufacture everything off-shore. So therefore they are wishing to develop nothing on-shore. Consistency dictates that they would want to retain the facility with the best track record of developing nothing on-shore. Hence WP.
 






Anonymous said:
Actually any decision to retain WP is consistent with the long-range business plan. The company wishes to develop and manufacture everything off-shore. So therefore they are wishing to develop nothing on-shore. Consistency dictates that they would want to retain the facility with the best track record of developing nothing on-shore. Hence WP.
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Thanks for clarifying Peter.
 






Merck sunk itself. With basic research, their focus became too narrow. With the implementation of those stupid "chips" that you had to save and spend to push a compound through was ridiculous. That destroyed programs because you had to guess the success of a compound and if you guessed wrong, you couldn't try something else because you spent all of your chips. Innovation went by the wayside and scientists were left to make uninformed decisions on which compound to move forward.

With respect to in vivo pharmacology, we need more of it to properly assess a compound before we waste tons of money just to watch it fail in man. Not enough attention is paid to preclinical in vivo pharm. It's a shame. The scientists want to get it right and develop the proper animal models to accurately assess compounds. No model is perfect, but with innovation we can try and come up with decent indicators. But leadership forces us to use non-indicative models and we have no say.

And after all of that effort to center neuroscience at WP? Too many changes too fast. Way to sink your own ship, mother Merck. Good scientists not allowed to show what they can do. Just fold and get it over with.
 












Anonymous said:
Politics, pure and simple!

MF actually discovered Singulair, Vioxx, Arcoxia, Fosomax, Cordaptive.
WP nothing in 20 years!

Great business decisions. Politics will kill the company.
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Ok...Singulair, Vioxx and Vioxx 2 (Arcoxia). Not the other two. And regarding West Point...and not drawing a distinction between where the chemistry was done and where the biology was done...here's a list for you.

Aggrastat, Cosopt, Cozaar, Crixivan, Fosamax, Hyzaar, Isentress, Pepcid, Trusopt...

besides. What the hell difference does it make? The company has failed under Peter Kim's leadership. Not WP failed. Not MF failed. Not RY failed. Peter Kim failed.
 






Anonymous said:
Ok...Singulair, Vioxx and Vioxx 2 (Arcoxia). Not the other two. And regarding West Point...and not drawing a distinction between where the chemistry was done and where the biology was done...here's a list for you.

Aggrastat, Cosopt, Cozaar, Crixivan, Fosamax, Hyzaar, Isentress, Pepcid, Trusopt...

besides. What the hell difference does it make? The company has failed under Peter Kim's leadership. Not WP failed. Not MF failed. Not RY failed. Peter Kim failed.
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What planet are you from? None of those were "discovered" in WP. Maybe they did some of the centralized research functions, that's all.

Isentress = IRBM (Rome)
Fosamax = Licensed in from Japan

Do your research!
 






Anonymous said:
What planet are you from? None of those were "discovered" in WP. Maybe they did some of the centralized research functions, that's all.

Isentress = IRBM (Rome)
Fosamax = Licensed in from Japan

Do your research!
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OK. Actually ... I did my research, which you clearly did not. Additionally, you also missed the point of the issue which is if you allow yourself to get into the pointless arguments of by-gone years on which site is better, you allow Peter Kim to win. He, Tillyer, Ford-Hutchinson and the rest would prefer you argue about site productivity of by-gone decades then focus on their total failures as managers, executives, scientists, or focus on how they have destroyed a once great company. Congratulations. You let them win.

Fosamax: Synthesized by Gentili in Italy. "Discovered" by Drs. Gideon and Sevgi Rodan of Bone Biology, West Point. In-licensed and developed by Gideon Rodan. Merck subsequently acquires Genitili. http://tinyurl.com/3t9pyce "Synthesized" does not always equal "discovered". As far as I know, it takes chemistry and biology to discover a drug. (If you are still at Merck, perhaps your ignorance of this basic fact is why the company is the laughing stock of the industry).

Isentress: The integrase inhibitor program was a JOINT program between IRBM and WP. All the biology was done at West POint under the initial direction of Emilio Emini and then Daria Hazuda. Med Chem was split between WP and IRBM with shared and ongoing activities at both sites. Isentress HAPPENED to be synthesized in Rome. While the patent may only include IRBM scientists (I sincerely apologize for not completing my homework assignment: I did not review whether WP chemists were included on the patent that covers Isentress or not), all the DESIGN work was jointly done, all the BIOLOGY was done at WP.

Once again, I must explain to you that "synthesized" and "discovered" are not the same activities. In modern drug discovery there is a synergy between chemists and biologists. This allows for the "discovery" of a drug within the compounds that have been synthesized. If this is too complicated for you to understand, I would refer you to the following. http://tinyurl.com/3mc93ft
 






Anonymous said:
OK. Actually ... I did my research, which you clearly did not. Additionally, you also missed the point of the issue which is if you allow yourself to get into the pointless arguments of by-gone years on which site is better, you allow Peter Kim to win. He, Tillyer, Ford-Hutchinson and the rest would prefer you argue about site productivity of by-gone decades then focus on their total failures as managers, executives, scientists, or focus on how they have destroyed a once great company. Congratulations. You let them win.

Fosamax: Synthesized by Gentili in Italy. "Discovered" by Drs. Gideon and Sevgi Rodan of Bone Biology, West Point. In-licensed and developed by Gideon Rodan. Merck subsequently acquires Genitili. http://tinyurl.com/3t9pyce "Synthesized" does not always equal "discovered". As far as I know, it takes chemistry and biology to discover a drug. (If you are still at Merck, perhaps your ignorance of this basic fact is why the company is the laughing stock of the industry).

Isentress: The integrase inhibitor program was a JOINT program between IRBM and WP. All the biology was done at West POint under the initial direction of Emilio Emini and then Daria Hazuda. Med Chem was split between WP and IRBM with shared and ongoing activities at both sites. Isentress HAPPENED to be synthesized in Rome. While the patent may only include IRBM scientists (I sincerely apologize for not completing my homework assignment: I did not review whether WP chemists were included on the patent that covers Isentress or not), all the DESIGN work was jointly done, all the BIOLOGY was done at WP.

Once again, I must explain to you that "synthesized" and "discovered" are not the same activities. In modern drug discovery there is a synergy between chemists and biologists. This allows for the "discovery" of a drug within the compounds that have been synthesized. If this is too complicated for you to understand, I would refer you to the following. http://tinyurl.com/3mc93ft
Click to expand...

You Sir, have indeed done your homework and are correct --- A+
 






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