Permacol

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After reading these posts I have determined that it takes a little more research to really get down to what the best product really is. Life Cell sounds like that cannot back up their process for their "Matrix Stabilizer" while Permacol is right out front and center with their explanation of the benefits of crosslinking. So in order to make up for Life Cell's lack of peer reviewed human data their best strategy is to run a smear campaign on something that they do not understand or prove to be uneffective which is crosslinking.
 




































Anonymous said:
This is interesting debate - but have any of you actually used these products?

As a practicing surgeon with a well established practice of using different biologics over the course of time as well as composites and pure synthetics clearly most of the comment is both uninformed and produced by people tied to different companies. From a practical users perspective, Permacol (and I'll stick to this one as it's the topic here) is indeed cross-linked and having used it for the last 6 years (pre-Tyco/Covidien) I have no problem with it in the situations in which I use it - reconstruction of abdominal walls (separation of components and in pts who have previously infected meshes to be removed), reconstructing defects such as the pelvic floor, and as an adjunct or bridge to allow coverage of an open abdomen following gross intra-peritoneal sepsis.

Perhaps you should take the educated view that the right product, in the hands of the right surgeon, with an understanding of both its properties and weaknesses, is best suited to the right patient.

Clearly most of the comments written here are uneducated, corporate speak with little review of the scientific literature. Perhaps on an even playing field with the different materials compared in the same types of patients the evidence becomes obvious for the benefit or not of each material.

Science always wins, any product that in the hands of a practicing surgeon works will survive the test of time - just look at hip joints!
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Does anyone know what role the bacterial infection could contribute to the rejection of synthetics or biologics?
 












I used to work for Tissue Science Laboratories selling Permacol many moons ago, Way before the company got sold off.. Back then, I had a bad feeling about putting a porcine product into the body. The surgeons were skeptical at times and I am so glad that I got out of that market. Sounds like things haven't changed too much from 2005 when I sold it direct. Not too many docs like it still...
 












It seems most of the posters here are US based. As a UK based sales rep with 2 years' experience selling Permacol, I thought I'd share my experiences.

Permacol is cross-linked with HMDI, not EDC. The level of cross linking and the agent used to cross link determines whether or not a Biologic implant will encapsulate. For this reason, you CANNOT lump Permacol and Collamend in the same boat and say they perform the same since they are both crosslinked. Over cross linking causes encapsulation and Collamend is proven to be over crosslinked. Permacol is crosslinked to a degree that is PROVEN not to inhibit integration in the slightest yet making it more resistant to bacterial and enzymatic breakdown.

Permacol is still a market leader in Biologics in the UK. I don't believe it would have retained this top position after many years if it really is as bad as people like to claim it is.

Finally, I say to Lifecell - PROVE to me that Permacol doesn't work. PROVE to me that Strattice is superior. You can't, because you have no peer reviewed human data. So all your bad-mouthing is complete conjecture.
 






Apparently the Brits have figured out how to polish a turd.

Sscientifically speaking, you are wrong.

Strattice and XenMatrix have shown favorable outcomes, 3-5 years postop in grade 3 and grade 4 hernias (I know the grading system sucks but it's all we got). These are in multi- institutional prospective studies.

Unless something has come out recently on Permacol the only stidies are in grade 1 and 2, single institution, retrospective, etc. Non- Crosslinked porcine is proven to work, in the cases where they are legitimately needed. My shoe leather would work in a clean inguinal.
 






Anonymous said:
Apparently the Brits have figured out how to polish a turd.

Sscientifically speaking, you are wrong.

Strattice and XenMatrix have shown favorable outcomes, 3-5 years postop in grade 3 and grade 4 hernias (I know the grading system sucks but it's all we got). These are in multi- institutional prospective studies.

Unless something has come out recently on Permacol the only stidies are in grade 1 and 2, single institution, retrospective, etc. Non- Crosslinked porcine is proven to work, in the cases where they are legitimately needed. My shoe leather would work in a clean inguinal.
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It is possible to polish a turd. I saw it on Mythbusters.
 






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