I am a rep and a patient. If I cannot tolerate statins and my LDL is high then I have to try something besides exercise and diet (I do both religiously). Whether it is a fibrate or Zetia or whatever does not matter. I was at one time on high dose Zocor and was tired of the horse pill. I did try Vytorin because it is smaller and want to see if it can achieve the same result as the horse pill. It did. You really think all DRs., PAs and NPs are walking geniuses? They simply chose the profession. The good ones know their limitations. Some think they are gods and you seem to put them on a pedestal. On your next round ask if they put their pants on the same way as you do or not.
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More Bad News for Zetia
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I am a rep and a patient. If I cannot tolerate statins and my LDL is high then I have to try something besides exercise and diet (I do both religiously). Whether it is a fibrate or Zetia or whatever does not matter. I was at one time on high dose Zocor and was tired of the horse pill. I did try Vytorin because it is smaller and want to see if it can achieve the same result as the horse pill. It did. You really think all DRs., PAs and NPs are walking geniuses? They simply chose the profession. The good ones know their limitations. Some think they are gods and you seem to put them on a pedestal. On your next round ask if they put their pants on the same way as you do or not.
Plenty of ways to lower cholesterol, do more research
Still don't think that if a "high risk patient" on Zetia has a coronary, that Merck can be sued. That would be like saying, "hey, I wear my seatbelt, so I cannot die in an accident". Taking a medication, like wearing your seatbelt, reduces the risk, but doesn't eliminate it.
you are so wrong, you are so uninformed.....(you must be very young, very naive or both)
Well, I launched Mevacor and so I know just enough to be "deadly". I am not going to take resin. I am not going to meditate to lower my cholesterol. I am terrible in following any guru diets. Atkins himself was not in great shape when he passed away either. I get all Merck drugs free. Zetia/Vytorin at one time looked promising and so I gave that a try. My current approach is Zocor + fibrate, regular exercise and moderate diet. You and I are not doctors. This is my best approach at this point without turning myself into a granola or follow some esoteric diets or daily mediation party with old hippies.
I have to be stupid to take red rice yeast sold at health food stores because its active ingredient is the same as Mevacor and I get the latter free or $4 a month at any pharmacy these days.Just a comment that boy, these bad studies certainly seem to land in Merck's lap more than other companies. What gives?
Has Zetia had a single large outcomes study that shows it is beneficial? Why do they keep pushing the big study further and further out? Why did they botch Enhance and SEAS?
Spin-meisters beware. You are all owned and getting punked!
Spin-meisters beware. You are all owned and getting punked!
You appear to be like that guy on the Geico commercial-what do you do, live under a rock?
Go look on any of the other pharma sites of Cafepharma. Or look at Pharmalot. Every company is dealing with lawsuits for drug related toxicity. Even in the face of patients with complex diseases that overlap with apparent toxic events. That is the real world.
Could it be the Merck's obsession in doing clinical trials to legitimize its own products and justify the price being charged? Even Pfizer was happy in marketing Lipitor and was in no hurry in getting outcome studies done quickly. We once were known to do high-quality large trials. Or could it be we now have doggie products and so no large fancy trials would help anyway?
Dr. Harlan Krumholz of Journal Watch Cardiology wrote: "This study reinforces that medications that change a risk factor do not necessarily change patient risk. Niacin, fibrates, and ezetimibe have so far failed to show that they improve patient outcomes in patients on statins. Be on guard for claims that are based only on how an intervention affects a risk factor — we need studies that show us the effect of these drugs on outcomes that patients experience."
You are comparing apples and oranges. Zeita has not shown drug related toxicity. It isn't the cause of a coronary. The fact that it can't prevent coronaries 100% of the time would be the defense. Don't believe for a minute that all lawsuits against pharma end up in favor of patients.
you cant use a drug to decrease LDL and at the same time increase plaque formation. this ought to be great when(if)we get our non-hdl indication. i notice there is no word about this from the company. either 1)they dont know about it(par for the course)or 2)they have no answer for it-yet. They have to figure out how to spin it. "Well, it was only 100 patients...." Yeah, yeah, yeah. Still, plaque increase? Nice going again. You cant blame this one on SP
your out of your mind. Merck will have to settle this out of court for big money. They will never let it go to the jury. Civil is not criminal, all you need is a preponderance of the evidence. Merck would get crushed if it went to trial. The screwed so many employees over people would line up as witnesses.
"He added that what can't be ascertained for certain from this study is whether the ezetimibe in the long-term-statin group is actually detrimental or whether the favorable effect of the statin has just started to wear off." (quote)
A lot of unanswered questions....blaming Zetia is not so clear-cut.
It does not have to be clear cut. That is why civil sucks so much. The jury will always be sympathetic to people. Company VS Company in a civil trial is anyone's guess. Company vs human element is bad news. Please remember half the jury is a bunch of dummies.
Agree juries are comprised of dummies. If you are correct (i.e., Merck will have to settle out of court for big money...and Zetia sales will plummet), then the next round of layoffs in sales may be sooner than we thought. Before November would be ideal for legacy SP. Strange that Merck has issued no statement on this latest controversy.
You guys who are more into journals and studies can argue over this until the Second Coming. Zetia can be a crappy product. But people take this, or a statin or whatever and continue to pig out, not exercising and just plain obese and blame a drug company for anything. When will people take responsibilities rather than relying on a pill entirely?
Merck and S-P have proven too many times that the less they say about Zetia/Vytorin the better. They will milk this placebo compound for as long as they can.