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Mirati - oncology?

































































Fierce Biotech: Lilly challenges Amgen, Mirati with early KRAS data

https://www.fiercebiotech.com/biote...data-heading-field-much-less-crowded-it-seems

KRAS inhibitors arrived on the market in May 2021 and December 2022 to much fanfare—but, if you ask Eli Lilly’s Loxo unit, the therapies have left much to be desired.

Amgen’s Lumakras and Mirati Therapeutics’ Krazati are “modestly effective” and have not led to the “dramatic advance for patients” that was initially thought possible when the once undruggable target was finally hacked, according to Jake Van Naarden, executive vice president at Lilly and CEO of Loxo@Lilly. Specifically, to make a real dent in the market, he said, KRAS inhibitors need to combine with standard-of-care PD-1 treatment—which in Loxo's opinion has not been smooth sailing for the first-to-market winners.
 




Fierce Biotech: Lilly challenges Amgen, Mirati with early KRAS data

https://www.fiercebiotech.com/biote...data-heading-field-much-less-crowded-it-seems

Exactly. What will the FDA find them??
KRAS inhibitors arrived on the market in May 2021 and December 2022 to much fanfare—but, if you ask Eli Lilly’s Loxo unit, the therapies have left much to be desired.

Amgen’s Lumakras and Mirati Therapeutics’ Krazati are “modestly effective” and have not led to the “dramatic advance for patients” that was initially thought possible when the once undruggable target was finally hacked, according to Jake Van Naarden, executive vice president at Lilly and CEO of Loxo@Lilly. Specifically, to make a real dent in the market, he said, KRAS inhibitors need to combine with standard-of-care PD-1 treatment—which in Loxo's opinion has not been smooth sailing for the first-to-market winners.