There are plenty of happy people at Amgen. Keep in mind that CafePharma generally is an avenue for disgruntled and unhappy people to express their thoughts and feelings.
There are many great things about Amgen, and of course, many things that people may not like. The work can be very challenging - those that state that their work is mindless may simply not be in the right position any longer. As with any company, there are product life cycles that do require the leadership to reset the board, hence the existence of expense management, headcount reductions (as well as hiring), etc. Our products are valuable to patients, we get paid a very good wage, our benefits are tremendous, and if you have skill sets outside of your work area, you can find avenues to put those to work.
Unhappy people complain. They complain about their job, they complain about their manager, they complain about executive leadership, they complain about pay, they complain about anything that makes them feel that they are being wronged. These unhappy people need to change the environment that makes them unhappy - change jobs, change company, change attitude, or dare if I say so, effect change on the elements that make them unhappy.
People complain the company/manager/leadership sucks but don't do anything about it - these people turn into a disease that needs to be cut out. Certainly there are people that do end up in working for someone they do not respect or like and that can cause problems. This is not specific to Amgen. What really is a shame that too many people are afraid to make changes to find happiness.
Amgen certainly isn't the same company it was 10 years ago - it is better and worse. The company evolves as it must. I for one do not like how my function is run at the EVP and SVP level. But I enjoy working for my manager and the two successive layers above him. Take the good and bad.
Great company, great management scattered throughout the company, great products. Also a company without problems - just like everywhere else. The grass sure looks greener on the other side to me sometimes, but it's an illusion. I have heard MANY more times from people that left the company that wished they hadn't.
Good luck to you.