DECLARE

[anonymous]

$3 billion in sales by 2023.

Must be the same person who projected our top end sales expectations 2 years ago.
Let me see, how many times has that number been reduced? "The bigger the lie the more people are likely to believe it." Except when AZ is involved of course.

 

[anonymous]

First of all HR people do not tell anyone layoffs are coming. They would not risk their jobs for YOU sparky. Second, the results from DECLARE were very, very positive. These are good times folks.

Bullshit. H.R. is and has been for decades, riddled with wanna be power brokers pretending to be able to influence personnel decisions to benefit their favorites. They are notorious at meetings for insinuating that they know the most intimate secrets of the H.Q. crowd. They have been the biggest spreaders of rumors of things to come by sharing reported insider secrets with their friends in the sales force. This has been true for many many years.
The truth is that they are in dead end jobs and are scoffed at by senior leadership.

 

[anonymous]

You obviously don’t understand the study!! Yes it’s better little man

No benefit in CV events,? that's not robust in my opinion.

 

[anonymous]

You obviously don’t understand the study!! Yes it’s better little man

No benefit in CV events,? that's not robust in my opinion.

 

[anonymous]

No benefit in CV events,? that's not robust in my opinion.

There’s s huge benefit in heart failure hospitalizations and CV death. Although MACE was non-inferior, it’s understandable (compared to Empa reg) given we had a large portion of patients that were “healthier” by comparison. Furthermore, Empa reg results were driven by the HF component.

 

[anonymous]

There’s s huge benefit in heart failure hospitalizations and CV death. Although MACE was non-inferior, it’s understandable (compared to Empa reg) given we had a large portion of patients that were “healthier” by comparison. Furthermore, Empa reg results were driven by the HF component.

Somebody needs to read the Empa study. For DECLARE, it’s the only one in the class that didn’t hit the 3 pt MACE.

 

[anonymous]

You obviously don’t understand the study!! Yes it’s better little man

Invokana said the same thing. Womp womp womp

 

[anonymous]

Invokana said the same thing. Womp womp womp

Go slither back in your hole!!!!!!!!

 

[anonymous]

Somebody needs to read the Empa study. For DECLARE, it’s the only one in the class that didn’t hit the 3 pt MACE.

Another AZ failure, just like Fasenra. just like Bevespi, just like the triple, Why can't we get it right!

 

[anonymous]

Another AZ failure, just like Fasenra. just like Bevespi, just like the triple, Why can't we get it right!

Just like SAVOR, EXCEL & now DECLARE! No “superiority” vs placebo so I anticipate no Primary Prevention indication. At worst, parity with EMPA. Let’s see how the Brand team packages and sells DECLARE. I’m cautiously optimistic however

 

[anonymous]

There’s s huge benefit in heart failure hospitalizations and CV death. Although MACE was non-inferior, it’s understandable (compared to Empa reg) given we had a large portion of patients that were “healthier” by comparison. Furthermore, Empa reg results were driven by the HF component.

 

[anonymous]

Somebody needs to read the Empa study. For DECLARE, it’s the only one in the class that didn’t hit the 3 pt MACE.

I think you need to look carefully at the patient population in each trial. Empa had 100% patients that already had a major CV event (very sick) and very likely to be suffering from HF. HF & CV death was the primary driver in the 3 pt MACE, not MI or Stroke.

 

[anonymous]

I think you need to look carefully at the patient population in each trial. Empa had 100% patients that already had a major CV event (very sick) and very likely to be suffering from HF. HF & CV death was the primary driver in the 3 pt MACE, not MI or Stroke.

you’re A fucking idiot! Read empa-reg dumb fuck and see that not 100% of patients had events. That will be your spin on your weak ass data with declare. “ Make the shit up as you go” is the AZ moto. Now go fuck yourself.

 

[anonymous]

you’re A fucking idiot! Read empa-reg dumb fuck and see that not 100% of patients had events. That will be your spin on your weak ass data with declare. “ Make the shit up as you go” is the AZ moto. Now go fuck yourself.

You have no idea what the poster was saying. Are you really this clinically inept? No one is saying that 100% had events. LMAO its scary that you have no idea how to read a clinical study at this point in your career. If you did you would understand what the OP was saying...I would break it down for you, but I would rather you look like an idiot in front of the doctor, so never mind.

 

[anonymous]

you’re A fucking idiot! Read empa-reg dumb fuck and see that not 100% of patients had events. That will be your spin on your weak ass data with declare. “ Make the shit up as you go” is the AZ moto. Now go fuck yourself.

Acting like a little bitch!!

 

[anonymous]

It is likely that the Declare results are the ones driven by HF. Empa reg showed superiority in CV Death and HF as separate endpoints. Declare has them as co-secondary endpoints. Show me how each performed independently then maybe you can talk about being on par with Jardiance.

 

[anonymous]

It is likely that the Declare results are the ones driven by HF. Empa reg showed superiority in CV Death and HF as separate endpoints. Declare has them as co-secondary endpoints. Show me how each performed independently then maybe you can talk about being on par with Jardiance.

LMAO.Jardiance Reps actually have to sell now...uh oh.

 

[anonymous]

AZ has its priorities backwards as usual. As a former employee (thank god I’m out) I never understood why they would failure after failure with their so called “pivotal” studies. Jardiance IS the go to for the SGLT2I class hands down. Lily and BI got it right. Declare didn’t do what they expected and won’t keep up vs Jardiance. AZ doesn’t know whether they’re coming or going majority of the time. Layoffs already started from what I heard a couple weeks ago. Not surprising.