This is an oversimplification.
In the old days - where these fines largely originated - companies picked a specialty and called on all of them. There was little targeting and no one ever considered the ramifications. It was call rate and educating psyches. In the last 10 years everyone knows the ramifications and has adjusted to it.
Reinsdorf is old news - he was back in the 90's. Rewriting history is a great thing for the government. It gives them another revenue stream. In all my years I've never seen or been part of the conspiracies that we have been fined for. Though when you look at the evidence, there is no doubt mistakes were made and are being paid for.
But cut the holier than thou shit.
If you were in CNS since launch you either had your head up your ass or you weren't paying attention. Here are the facts Jack. First we came out for manifestations of psychotic disorders. Generally speaking, we had an indication to treat schizophrenia. As Michael Hickey said, nobody thought Seroquel would do more than $300 million.
But sheezam and surprise, the doctors started using it as a sedative and an anxiolytic because it works pretty well in that department. Then we targeted the elderly, just like Eli Lilly. I remember because one of my responsibilities was to call on state geriatric facilities. We did great there, nobody sundowned because they were so sedated they couldn't move, the staff loved Seroquel. Then we took Hamner's worthless study of 13 or so patients, I can't remember but I do believe it was less than 20, and went after the VA's, targeting patients with PTSD. I know, I helped target the VISN's in my region. Then on to targeting children, we had a wonder drug with no side effects! Morally, there was no reason to use any other drug because of the EPS and weight loss. Then we targeted bipolar disorder before we received an indication for it. No targeting?
At the time, all I cared about was making bonus and selling more of this wonder drug. I actually believed it had few side effects but was starting to get feedback and have some doubts about its efficacy and side effects. It wasn't until several years ago that I told my manager that I would no longer call on child psychiatrists and went so far as to caution all of them about weight gain. Many had already slowed down considerably in their use of Seroquel, for good reason.
Oversimplification? Well, how much can you put in four or five paragraphs? It's a fact that we promoted off label, illegally, and with intent. AZ has been on Corporate Integrity Agreements the entire time I have worked for them. Oh, and it's Reinstein, not Reinsdorf. He was in the early 2000s, up until about 2004 which makes me doubt you ever worked for CNS and makes it obvious you know nothing about its history. The huge fines have been paid and there will be more paid out, it is ongoing. So it ain't ancient history ass breather, read Fierce Pharma. You obviously have no clue what you are talking about. The history is as plain as your ignorant face, and AZ's big revenue stream is about to be cut off by generic Seroquel.