Alzheimer's positions

[anonymous]

Let external candidates take those roles, do not entertain their discussion of launching the Alz med, stay where you are.

 

[anonymous]

No need to be concerned about this anymore. This is clearly a dead topic. Although it is sad for Alz patients.

https://endpts.com/roches-comeback-...-phiii-flop-keeping-biogen-eisai-in-the-lead/

 

[anonymous]

No need to be concerned about this anymore. This is clearly a dead topic. Although it is sad for Alz patients.

https://endpts.com/roches-comeback-...-phiii-flop-keeping-biogen-eisai-in-the-lead/

I can’t say that many were even cautiously optimistic about this drug. If the data was better than this, that would have been a win. Alzheimer’s will be the straw that breaks every camel’s back

 

[anonymous]

I was an FRM at Biogen. Believe me, please think very carefully before entertaining any job in the Alzheimer's space for many reasons, but here are a few:
1. The Beta Amyloid Hypothesis has not been proven. There were several drugs prior to Biogen's ADU. Outside of initiating therapy earlier versus later in the disease progression, there isn't much difference.
2. Most neurologists with good reason believe the Beta Amyloid MOA is barking up the wrong tree
3. Neurologists won't fight for you. If you have worked with them in the past, such as multiple sclerosis, you'll realize they are very weak and unlike other areas of medicine, won't fight for a drug.
4. Coverage will be a nightmare
5. The hospitals, independent infusion centers, neurologists, c-suite executives all feel their time and money was completely wasted in several meetings over 2 years. They won't make that mistake again when people try to go out and "pre-condition" the market and set up a drug pathway. You will get tons of no's as many have been burned. Even as a new company, you will be laughed at and many doors will be slammed in your face as a key account manager, frm, and sales person.
I say this very respectfully. Please rally think about what you are doing. As much as an Alzheimer's drug is desperately needed, it is sill way too early. I believe the turn will be a new drug with an entirely different MOA.

You were right. Good call!

 

[anonymous]

You were right. Good call!

Thank you. Sorry to say I am right but being at Biogen in thee Alzheimer's space was the worst couple of years of my entire career. I'm not surprised by any of this. The Amyloid hypothesis is climbing up thee wrong tree.