I can't believe this is the direction medicine is headed. Retina specialists are an arrogant group, but they are trying to do the right thing for patients. This fucking group of people (Protocol for: Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide once weekly for the treatment of obesity.) and this company (eli lilly) is beyond unethical. Put down the 3 bags of chips, 3 bags of candy, and 3 trips to the fast food joints every day and start eating differently. Also, get off the couch and go for several walks per day. Only eat three meals per day from 7 am to 6 pm (no snacking). You'll lose weight healthily and naturally. You don't need this shit drug.
1. 150 minutes of physical activity per week isn't enough.
2. Eat 1500 calories per day, less than 50g of added sugar, less than 80g of fat, and less than 2,000mg of sodium.
3. An ethical set of objectives would read "To Evaluate" not "To Demonstrate"
4. People should be fasting for at least 8 hours every day of the week, not just when showing up to these shit-biased visits.
5. The food companies want to make money from you eating unhealthy, the drug companies want to make money from you being fat from eating unhealthy, and the government pretends like they have your best interests in mind while profiting from both the food and drug companies.
https://www.nejm.org/doi/full/10.1056/NEJMoa2206038
https://www.nejm.org/doi/suppl/10.1056/NEJMoa2206038/suppl_file/nejmoa2206038_protocol.pdf
"Protocol for: Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide once weekly for the treatment of obesity.
N Engl J Med 2022;387:205-16. DOI: 10.1056/NEJMoa2206038
This trial protocol has been provided by the authors to give readers additional information about the work."
"
PROCEDURES
After a 2-week screening period, participants were randomly assigned in a 1:1:1:1 ratio to receive tirzepatide at a dose of 5 mg, 10 mg, or 15 mg or placebo, administered subcutaneously once weekly for 72 weeks as an adjunct to lifestyle intervention. Lifestyle intervention included regular lifestyle counseling sessions, delivered by a dietitian or a qualified health care professional, to help the participants adhere to healthful, balanced meals, with a deficit of 500 calories per day, and at least 150 minutes of physical activity per week."
"To demonstrate that tirzepatide 10 mg QW is superior
to placebo for:
• percent change in body weight AND
• percentage of participants with ≥5% body
weight reduction
AND/OR
To demonstrate that tirzepatide 15 mg QW is superior
to placebo for:
• percent change in body weight AND
• percentage of participants with ≥5% body
weight reduction"
"On all office visits, study participants should be reminded to report to the site
before taking study drug (s) in a fasting condition, after a period of
approximately 8 hours without eating, drinking (except water), or any significant
physical activity. Since some screening procedures need to be completed in the
fasting state, Visit 1 may be conducted over more than 1 day to ensure necessary
conditions are met."