A new class of anticoagulant drugs called factor Xa inhibitors have wrestled away significant market share from Warfarin, a decades-old drug widely used to prevent clots in heart disease patients and hip and knee surgery patients. However, until last year's approval of Portola Pharmaceuticals' (NASDAQ:PTLA) Andexxa, there wasn't an FDA-approved medication on the market to reverse their effect -- a dangerous proposition for patients at risk of falling or emergency surgery.
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