Neurofilament as a surrogate endpoint goes on trial in tofersen adcomm

Biomarkers as a surrogate endpoint in ALS will go on trial on March 22 as Biogen and Ionis’s tofersen faces the FDA’s Peripheral and Central Nervous System Drugs Advisory Committee.

Tofersen, which Biogen licensed from long-time collaborator Ionis in 2018, is being developed to treat superoxide dismutase 1 amyotrophic lateral sclerosis (SOD1) ALS.