• Thurs news: Lilly’s weight-loss drug prevents diabetes. Merck pays $588M for bispecific. Amgen speaks out about bone density issues with obesity drug. PTC gets gene therapy approval. JNJ’s 340B legal fight. See more on our front page


Why does stock keep dropping?









Natural GLP1 was discovered in the 1980s and has a duration of action of a few minutes. Laboratory engineered artificial GLP1 lasts for days. These long acting synthetic GLP1 hormones have been previously studied in diabetics. All diabetics are at increased risk of pancreatitis. If both the placebo control and medication arms of diabetic studies both had diabetics, the studies may not have been large enough to have the statistical power to show true extent of pancreatitis these artificial hormones cause. Long acting insulin makes sense in diabetics because it gives defective pancreas a rest and other cells need energy anyway. It makes absolutely no sense for mega doses of long acting artificial GLP1 to cause constant pancreatic stimulation to produce and store insulin. The insulin release in pancreas is “Glucose Dependent” and happens less because of lower calorie intake because of weight loss. Pancreatitis is in your package insert and is a risk factor for pancreatic cancer. What other unknown effects do these artificial laboratory hormones have on the body? These products are crazy for temporary weight loss. FDA is keeping track of pancreatitis, pancreatic cancer, and thyroid cancer in these artificial hormones. Let’s see what happens to stock price.
 




Dollars generated from insulin products have decreased because of government action. Company was desperate for new revenue stream. They used their expertise in making long acting insulin to the GLP1 hormone. Why did millions of years of evolution make natural GLP1 last for a few minutes? Today, mega doses of long acting laboratory artificial hormone GLP1 is being prescribed to other wise healthy overweight patients. The healthy pancreas suffers from constant stimulation to produce and store insulin. This stored insulin is released after meals and is “Glucose Dependent”. If people are eating less, less insulin is released. This is modern chemistry at its finest. Stock price is main consideration. Executives need to cash stock options. Why not use a gastric balloon to feel full? Once weight loss goals are achieved, balloon can be removed.