Natural GLP1 was discovered in the 1980s and has a duration of action of a few minutes. Laboratory engineered artificial GLP1 lasts for days. These long acting synthetic GLP1 hormones have been previously studied in diabetics. All diabetics are at increased risk of pancreatitis. If both the placebo control and medication arms of diabetic studies both had diabetics, the studies may not have been large enough to have the statistical power to show true extent of pancreatitis these artificial hormones cause. Long acting insulin makes sense in diabetics because it gives defective pancreas a rest and other cells need energy anyway. It makes absolutely no sense for mega doses of long acting artificial GLP1 to cause constant pancreatic stimulation to produce and store insulin. The insulin release in pancreas is “Glucose Dependent” and happens less because of lower calorie intake because of weight loss. Pancreatitis is in your package insert and is a risk factor for pancreatic cancer. What other unknown effects do these artificial laboratory hormones have on the body? These products are crazy for temporary weight loss. FDA is keeping track of pancreatitis, pancreatic cancer, and thyroid cancer in these artificial hormones. Let’s see what happens to stock price.