hey hey hey....wait one damn minute mr/ms takeda rep. you can talk trash all you want but you just crossed the line!! get your facts straight: explosive diarrhea? yes... reps are idiots? well...yes... but killing mice??? I just can't stand for that. CPR was administered during the trials and I was the manager rodent resuscitation during the Linzess trials. And yes, we had some wonderful little white mice who struggled with the side effects of Linzess. And yes, some of them coded. But me and my strong, capable team brought them back to life! do you know how difficult it is to get your little pinky finger just in the right spot to deliver chest compressions?? My team worked tireless hours on that exercise for emergencies just like these. And when one little fella came to the first thing he squeaked was "hey dude, watch out...i'm not constipated anymore and i'm about to blow a massive log right onto you." it brought tears to my eyes! so for the record, Linzess was effective for this particular white mouse. Unfortunately, this was not a LOCF trial so he didn't get credit in the study. But rest assured he is shitting freely now while he awaits the trial on NMDG1436 which will be a blockbuster for chronic elephantiasis. So go back to your takeda board and spread that around.