They'll never prescribe it

Anonymous

Guest
You can build it but they won't come. You have several problems with your managements plan of action. The territories are too small to support the activities of reps. Orthos won't prescribe it when they have CIII hydrocodone options, anesthesiologists prefer procedure over long acting opioids, and IMs won't touch it with a ten foot pole. PM&Rs will prescribe it but there are only a hand full in each territory. That means that some territories will have to be realigned and some of you will lose your jobs even if you do your jobs right. Managed care is going to be the next elephant in the room. That will be the death blow at month 13 of your new business adventure.
 






I completely disagree! First I would like to say I don't work for Zogenix (But I certainly which I did).

The benefits of Zohydro far out way the addiction epidemic issue this country has. If people want to abuse something they are going to find a way to do it regardless. But having a pure hydrocodone without the dangers of liver killing acetaminophen is something that doctors and patients (who really need opiods for long-term pain) have both been waiting for.

If hydrocodone is the best pain option for a patient, they should be able to have that option without the risk of killing themselves due to liver failure bc they couldn't get hydro without the proven dangers of long term APAP.

I believe Zohydro ER will be a blockbuster drug and once they get an abuse deterrent delivery system it will be even that much better. I highly reccommend buying Zogenix stock while the price is below $5. I think it climbs over $10 within 1-2 months of launch.
 






You can build it but they won't come. You have several problems with your managements plan of action. The territories are too small to support the activities of reps. Orthos won't prescribe it when they have CIII hydrocodone options, anesthesiologists prefer procedure over long acting opioids, and IMs won't touch it with a ten foot pole. PM&Rs will prescribe it but there are only a hand full in each territory. That means that some territories will have to be realigned and some of you will lose your jobs even if you do your jobs right. Managed care is going to be the next elephant in the room. That will be the death blow at month 13 of your new business adventure.

Small territories? Obviously you don't work here.
 






I completely disagree! First I would like to say I don't work for Zogenix (But I certainly which I did).

The benefits of Zohydro far out way the addiction epidemic issue this country has. If people want to abuse something they are going to find a way to do it regardless. But having a pure hydrocodone without the dangers of liver killing acetaminophen is something that doctors and patients (who really need opiods for long-term pain) have both been waiting for.

If hydrocodone is the best pain option for a patient, they should be able to have that option without the risk of killing themselves due to liver failure bc they couldn't get hydro without the proven dangers of long term APAP.

I believe Zohydro ER will be a blockbuster drug and once they get an abuse deterrent delivery system it will be even that much better. I highly reccommend buying Zogenix stock while the price is below $5. I think it climbs over $10 within 1-2 months of launch.

...out weigh, not out way... geeze. On another note, Zogenix doesn't have an abuse deterrent delivery system. There are multiple companies going after the abuse deterrent form of long-acting hydrocodone so there are no guarantees that Zog will get to the finish line first.
 












You can build it but they won't come. You have several problems with your managements plan of action. The territories are too small to support the activities of reps. Orthos won't prescribe it when they have CIII hydrocodone options, anesthesiologists prefer procedure over long acting opioids, and IMs won't touch it with a ten foot pole. PM&Rs will prescribe it but there are only a hand full in each territory. That means that some territories will have to be realigned and some of you will lose your jobs even if you do your jobs right. Managed care is going to be the next elephant in the room. That will be the death blow at month 13 of your new business adventure.

Anyone who prescribes extended-release opioids in significant numbers will see a role for Zohydro for some patients. It will get prescribed. How much is another question. This won't be a billion dollar drug, but it will probably be enough for a company like Zogenix to keep the fires burning.
 






Anyone who prescribes extended-release opioids in significant numbers will see a role for Zohydro for some patients. It will get prescribed. How much is another question. This won't be a billion dollar drug, but it will probably be enough for a company like Zogenix to keep the fires burning.

Agree. This will get utilized because of the molecule without tylenol and because of the sales force. These people hired the best.
 






Agree. This will get utilized because of the molecule without tylenol and because of the sales force. These people hired the best.

Good try ol chap, but you have got it all wrong, it will have negligible utilization. If you aren't targeting orthos, all you have left are neuros, anesthesiologists who treat chronic pain, and PM&Rs. Once again, anesthesiologists who treat chronic pain will do so by procedure, so they won't support your salaries and expenses by prescribing a schedule II hydro. They use CIII hydros because they are easier on admin costs. The PM&Rs will use it but very little because it is going to be a headache to prescribe due to cost and lack of managed care. Work comp has buttoned down the meds they will approve, so although it is a lions share of your targeting plan, you won't see much from WC. Your sales force may be sweet and cute and all that but that won't make you profitable.
 






Good try ol chap, but you have got it all wrong, it will have negligible utilization. If you aren't targeting orthos, all you have left are neuros, anesthesiologists who treat chronic pain, and PM&Rs. Once again, anesthesiologists who treat chronic pain will do so by procedure, so they won't support your salaries and expenses by prescribing a schedule II hydro. They use CIII hydros because they are easier on admin costs. The PM&Rs will use it but very little because it is going to be a headache to prescribe due to cost and lack of managed care. Work comp has buttoned down the meds they will approve, so although it is a lions share of your targeting plan, you won't see much from WC. Your sales force may be sweet and cute and all that but that won't make you profitable.

Odd. Anesthesiologists doing "procedures" don't do Vicodin. They do anesthesia! Pain docs are usually board-certified in anesthesia but any anesthesiologist in private practice as a pain doc will use a ton of ER opioids. They'll use Zohydro as one tool in their toolbox. Managed care and cost is an issue for every ER opioid in this space. OxyContin is no longer the indomitable bear it once was. The new formulation doesn't give patients the same pop, so now there is no vocal patient base screaming for their OxyContin. It's a level playing field. Purdue doesn't have the formulary leverage it once had. New ball game. A small company with a decent product that isn't worried about an outrageous and stupid price point will make some money. Not huge, but some.
 






Good try ol chap, but you have got it all wrong, it will have negligible utilization. If you aren't targeting orthos, all you have left are neuros, anesthesiologists who treat chronic pain, and PM&Rs. Once again, anesthesiologists who treat chronic pain will do so by procedure, so they won't support your salaries and expenses by prescribing a schedule II hydro. They use CIII hydros because they are easier on admin costs. The PM&Rs will use it but very little because it is going to be a headache to prescribe due to cost and lack of managed care. Work comp has buttoned down the meds they will approve, so although it is a lions share of your targeting plan, you won't see much from WC. Your sales force may be sweet and cute and all that but that won't make you profitable.

ol chap? sweet and cute? who do you think you are, smart@ss?
 






Odd. Anesthesiologists doing "procedures" don't do Vicodin. They do anesthesia! Pain docs are usually board-certified in anesthesia but any anesthesiologist in private practice as a pain doc will use a ton of ER opioids. They'll use Zohydro as one tool in their toolbox. Managed care and cost is an issue for every ER opioid in this space. OxyContin is no longer the indomitable bear it once was. The new formulation doesn't give patients the same pop, so now there is no vocal patient base screaming for their OxyContin. It's a level playing field. Purdue doesn't have the formulary leverage it once had. New ball game. A small company with a decent product that isn't worried about an outrageous and stupid price point will make some money. Not huge, but some.

Okay, Grasshopper, listen and learn: anesthesiologists shouldn't "DO" Vicodin, they prescribe Vicodin for acute pain. They do procedures like injections, pumps, etc., for chronic pain. They prefer procedure over pills for long acting because it works AND they make more money$$$$. Get it? Tune in later for your next lesson in pain management..... Thank you, you are dismissed!! :)
 












That game has changed. Lots of regulation and good luck stocking all those doses at the pharmacy level.

When I sold oxy in the hay day it was a dream. Good luck in today's world.
 












Okay, Grasshopper, listen and learn: anesthesiologists shouldn't "DO" Vicodin, they prescribe Vicodin for acute pain. They do procedures like injections, pumps, etc., for chronic pain. They prefer procedure over pills for long acting because it works AND they make more money$$$$. Get it? Tune in later for your next lesson in pain management..... Thank you, you are dismissed!! :)

OK Mr. KNOW IT ALL

Doctors will be afraid to write a product today with absolutely no
abuse resistant technology

Zohydro can be crushed, chewed, snorted.....you name it

Now the drug addicts will want it as will the drug dealers but

ISTOP also comes into play......
 






Okay, Grasshopper, listen and learn: anesthesiologists shouldn't "DO" Vicodin, they prescribe Vicodin for acute pain. They do procedures like injections, pumps, etc., for chronic pain. They prefer procedure over pills for long acting because it works AND they make more money$$$$. Get it? Tune in later for your next lesson in pain management..... Thank you, you are dismissed!! :)

Thank you. I am so ashamed.

But the interventional pain specialist is not the target audience. It's the noninterventional pain specialist treating chronic pain. There are lots out there.
 






Thank you. I am so ashamed.

But the interventional pain specialist is not the target audience. It's the noninterventional pain specialist treating chronic pain. There are lots out there.

OK Mr. KNOW IT ALL

Doctors will be afraid to write a product today with absolutely no
abuse resistant technology

Zohydro can be crushed, chewed, snorted.....you name it

Now the drug addicts will want it as will the drug dealers but

ISTOP also comes into play......
 






OK Mr. KNOW IT ALL

Doctors will be afraid to write a product today with absolutely no
abuse resistant technology

Zohydro can be crushed, chewed, snorted.....you name it

Now the drug addicts will want it as will the drug dealers but

ISTOP also comes into play......

How many generic oxymorphone ER scripts are being written? How many 30-mg pills of immediate-release oxycodone (not abuse deterrent)? Payers don't believe abuse-deterrent technology works and won't pay a premium for it. I guarantee you, if it is a choice between ADF OxyContin and non-ADF Zohydro and the price is right, payers will follow the price. If Zogenix is smart they'll undercut Purdue substantially.
 






How many generic oxymorphone ER scripts are being written? How many 30-mg pills of immediate-release oxycodone (not abuse deterrent)? Payers don't believe abuse-deterrent technology works and won't pay a premium for it. I guarantee you, if it is a choice between ADF OxyContin and non-ADF Zohydro and the price is right, payers will follow the price. If Zogenix is smart they'll undercut Purdue substantially.

What's next, Zogenics, long acting heroin...? Hey, if it's cheap enough, payers will follow the price?