Stupid Investors

Anonymous

Guest
did you see the Yahoo message board after the last investor call ? Nader left investors with the impression that NPS558 might work in osteoprosis. DID ANYONE TELL THESE IDIOTS THAT NPS558 WAS FILED WITH THE FDA FOR OSTEOPOROSIS AND WAS NEVER APPROVED

PREOS aka NPS558 was the first round of investor lawsuits about lying to the public

PT Barnum said you can fool some of the people some of the time... only Nader says you can fool all of the people all of the time

NPS = No Patients Survive
 






Preos, AKA NPS558, is already approved in Europe for Osteoporosis. NPS has an agreement with Nycomed who sell Preos in Europe for them. Its call Preotact in Europe, but its still Preos.

In the US, Preos was not denied, but rather given an approvable letter. An approvable letter is an official notification from the FDA that contains conditions that must be satisfied prior to obtaining final U.S. marketing. The FDA wanted NPS to do an additional study on the elevated calcium levels in the body after taking Preos. The study would cost millions which at the time, NPS did not have that type of money. It was decided to focus on Gattex instead of doing another Preos study since Gattex Phase III study was underway and that drug was closer to approval.

Listed below is from a 2006 press release on the Preos Approvable letter.

March 10 /PRNewswire-FirstCall/ -- NPS Pharmaceuticals,
Inc. (Nasdaq: NPSP) announced today that the U.S. Food and Drug Administration
(FDA) has determined that the company's new drug application (NDA) for
PREOS(R) (parathyroid hormone [rDNA origin] for injection) is approvable. The
FDA indicated that the company's pivotal study with PREOS demonstrated
significant fracture risk reductions in postmenopausal women with
osteoporosis, but noted the higher incidence of hypercalcemia with PREOS
compared to placebo. The agency expressed concern regarding hypercalcemia
associated with the proposed daily dose of PREOS and has requested additional
clinical information. The agency also requested additional information
regarding the reliability and use of the injection device for delivery of the
drug.
NPS has requested a meeting with the FDA to address these issues and to
determine whether existing data are sufficient to respond to the agency's
concerns or whether additional studies will be required. Subsequent to these
discussions, NPS will be better able to project the timing for approval and
launch of PREOS.

About PREOS
PREOS is recombinant human parathyroid hormone (PTH). NPS has studied
PREOS in a number of clinical settings to document its safety and effects on
bone. The pivotal Phase 3 study, known as TOP (Treatment of Osteoporosis with
PTH), was a multi-center, randomized, double-blind and placebo-controlled
clinical trial designed to evaluate the potential of PTH to reduce the risk of
first and subsequent vertebral fractures in post-menopausal women.
In the TOP study, PREOS demonstrated a statistically significant reduction
in the risk of new vertebral fractures in women with and without pre-existing
osteoporosis-related fractures. Results from the TOP study have been the
foundation of both the E.U. and the U.S. marketing authorization applications.
 






It appears like the company is gearing up approval for Gattex third quarter. I am considering applying for this position. How stable is the company? From these posts it appears to have a lot of problems with the drugs in the pipeline... What's really going on?
 












Gattex PhIII wasn´t underway in 2006.
The drug has been recently approved by EMA in the EU, the FDA has extended the review of the NDA submitted in Jan from Sep to Dec.
I have never worked for NPS but a long-time contractor. From what I know I can tell that this is certainly an interesting place to work at. Competent people at the operations level, good managers who believe in empowerment.
Interestingly, the company always seems to find a way out of its troubles.
As mentioned, they were in dire straits when the FDA did not grant outright approval for Preos, they had literally gone all-in on that.
Yet they manged to keep the ship afloat long enough for Gattex and another indication for parathyroid hormone. It´s going to be interesting how this will turn out.
In any way, from my perspective NPS in certainly a good company to work WITH.
 






Yeah I agree they are good to work for however, they are being very cheap and not going to offer a lot to the new reps.. you wont start to make money for two years the way they're being with payouts... low base salaries and a bonus based on everyone making that national goal, huge geographies and small car allowance.... it will be interesting to see who gets hired because they're not paying for experience and talent, they are shooting low because they can...
 
























salaries higher. car allowance going to be based on runzhimer, which sucks. i have a 7 year old high end vehicle and with runzheimer, you are required to have a vehicle within 2 years old

I have experience with Runzheimer as they administered the fleet program with 2 previous startups I was with.

It all depends on what vehicle NPS uses as a benchmark.

A previous emlployer used a Toyota Camry SE with a V6, which retails for about 25K. This was a generous choice compared with other companies who benchmark a base Ford Fusion valued at 19K and gets 35mpg.

So if you buy a car for more than the benchmark vehicle price, and it gets fewer miles per gallon and costs more to insure...you're hosed.

My advice is buy used (because Runzheimer doesn't accurately account for depreciation regardless of what they say), buy fuel efficient and buy cheap. Otherwise the car will be a major expense.
 






salaries higher. car allowance going to be based on runzhimer, which sucks. i have a 7 year old high end vehicle and with runzheimer, you are required to have a vehicle within 2 years old

Your full of it! Runzheimer can set up many different car allowance packages based on what the company wants to spend. I have used Runzheimer in the past and they can set it up with vehicles within 4, 5, or 6 years of the model year, and this can change if the company wants. My current company made several changes over the past two years that made it quite lucrative for the reps that weren't driving new higher end cars. You dont know what your talking about or aren't smart enough to negotiate something more.
 






Companies can only reimburse the max set by the IRS if they want to keep it tax free. Most will go slightly below to ensure their compliant. Amounts above the IRS limit become taxable to the employee.
 






last time I worked with runzheimer, many of us decided on bmw's. best to just buy it outright then replace the funds as they roll in. i literally broke even. the 3 series xi is just awesome in the snow and even more so with snow tires. unstoppable which is great as you need to be in the field in any weather when the territories are large.
 






Great job opportunity...leave for your territory Sunday night...come home Friday afternoon and try to get one patient per month.....while your wife is banging' the post man......
 












Well I am an investor (got in at an average of $8.30 a share) and am thrilled with the work you guys are doing. All you NPS reps just keep selling and hang on to your stock. You are going to make a ton of money over the next few years. Call it retirement money, kids college fund, new house, or just eff you money. It's coming just keep selling. You are helping patients too.
 






I'm a stupid investor who bought 10,000 shares when the stock was at $3.00. Sold when it hit $34.00.

Thanks Francois!!

My only regret is not buying more, but that would just be greedy.