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If you're 50 years of age and older, no debt, house paid off, kids gone, you just get to the point where it's just not worth the ridiculousness of the job anymore.  Especially if you have other talents before you got into pharma.  Thank goodness I took the "hardship" severance package because I sure don't miss all of the Bulls*&t all of you who are still there are going through.  Life's TOO short!!!