Question on what to take

[Anonymous]

I goto my Dr. next Friday and i am going to have to change meds. My body or mental state can not handle this OP formula anymore. I currently take 2 80mg Oxy's every 8 hrs and 2 30mg roxicodone every 8 hrs. I am considering Opana. I have waiting and prayed that Purdue would have changed back after this long. If someone has some inside info that it could happen by next Friday or soon i would stay with it till the old formula is back. But if i change to opana will i have any withdrawls from not taking the oxy? And how many opanas should i be getting per month to equal my current Oxy dosage. I have held on as long as i could. You can tell when your body is not excepting a drug and mine is not. Any advice would be great. Thanks in advance!

 

[Anonymous]

I goto my Dr. next Friday and i am going to have to change meds. My body or mental state can not handle this OP formula anymore. I currently take 2 80mg Oxy's every 8 hrs and 2 30mg roxicodone every 8 hrs. I am considering Opana. I have waiting and prayed that Purdue would have changed back after this long. If someone has some inside info that it could happen by next Friday or soon i would stay with it till the old formula is back. But if i change to opana will i have any withdrawls from not taking the oxy? And how many opanas should i be getting per month to equal my current Oxy dosage. I have held on as long as i could. You can tell when your body is not excepting a drug and mine is not. Any advice would be great. Thanks in advance!

I seem to recall reading that oxycodone is metabolized into oxymorphone. If that's the case, the two drugs probably act on all the the same opioid receptors, so you may not have to deal with incomplete cross-tolerance when calculating the conversion.

Without incomplete cross-tolerance being a factor and with no other factors to consider, it should be a straight two to one ratio, so instead of taking two 80mg oxys every 8 hours, you might take 2 40mg Opanas every 8 hours.

Given the absorption problems of the OP's however, your doctor might start you on 2 opana's every 12 hours. If I'm wrong about not have to deal with incomplete cross-tolerance, your doctor might prescribe less, so hang onto your breakthrough medication, just in case.

You might also consider methadone instead of Opana. It is very strong, and is very long lasting without the need for a special "sustained release" matrix. It is also extremely cheap. My doctor offered it to me once, but I declined because the only thing I knew about it at the time was that there was a social stigma associating with taking it (but then there is also a social stigma associated with taking oxycontin, because of all the bad press). I could not suggest a dosage, because incomplete cross tolerance probably will be a factor with methadone.