Lonnel Coats, Frank Ciriello, and Michael Obrien have long lost their drive in Eisai and should have been gone if Japan listened. Many years ago, these senior leaders become complacent and stop doing their very best. They needed a kick in the pants. Unfortunately, they eliminated all those who could challenge them.
In the case of Frank and Michael, they were protected by Lonnel every time they were challenged by others. Many good people were let go from Eisai because they decided to change the old and obsolete business model. Hopefully removing Lonnel is the first warning by Japan to people like Frank and Michael. Hopefully Japan has learned about the shortcomings of these individuals and soon they will transition them out. If the new leaders are serious about making Eisai better, they need to challenge the business model that was implemented by FC and OB. They need to bring new leaders and give them opportunities and protection to challenge Michael and Frank.
There are serious problems in Eisai and Japan does not know about them. The problems were buried by Lonnel because he was complacent and was already thinking about the next chapter of his life many years ago.