Nucynta Surprises

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Anonymous

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The more I learn, the clearer it becomes that the decision to purchase Nucynta Brand was not particularly well-informed.

Evidence suggests that Depomed overestimates the value of the DPN indication, doesn't understand that the market for CII's is shrinking and is unaware of every marketing plan implemented by J&J since January 1999.

Unless there's a rabbit in the hat somewhere, plans include rehashing marketing plans that already fell flat (with both a dedicated, single-drug sales force and a 1200 rep sales force that had plenty of incentive to sell under the J&J umbrella) and simply fielding "better reps with better management."

If this is the case, in my opinion making those interest payments in coming years is going to be quite the hurdle. Expect the cattle prods to come out Big Time.
 






Anyone with half a brain knows that the value of a DPN indication is priceless. And I firmly believe that Depomed will take this drug to a new level based on that indication only. They have done wonders with a drug with a very narrow window of opportunity based on it's indication (Gralise). It's the right drug for the right company and fits perfectly into their product mix. They'll do a lot better than J and J.
 






Anonymous said:
Anyone with half a brain knows that the value of a DPN indication is priceless. And I firmly believe that Depomed will take this drug to a new level based on that indication only. They have done wonders with a drug with a very narrow window of opportunity based on it's indication (Gralise). It's the right drug for the right company and fits perfectly into their product mix. They'll do a lot better than J and J.
Click to expand...

You're an idiot! Physicians think Gralise is a joke and it has 0 formulary coverage. The value of a DPN indication means Nothing given the decline in the CII market. Do your homework ya dumbass. LMAO at you!!!!
 






Anonymous said:
Anyone with half a brain knows that the value of a DPN indication is priceless. And I firmly believe that Depomed will take this drug to a new level based on that indication only. They have done wonders with a drug with a very narrow window of opportunity based on it's indication (Gralise). It's the right drug for the right company and fits perfectly into their product mix. They'll do a lot better than J and J.
Click to expand...

Wait until you are asking your neurologist-customer to write for a CII opioid to treat his next five DPN patients with pain. At a time when physicians are under tremendous pressure to curtail opioid use, what do you think he'll tell you? Do you have an iota of a clue where opioids fit in treatment of neuropathic pain? Has Depomed's promotion of Gralise changed an entire clinical treatment paradigm? (Not a rhetorical question; if it has, then hat's off to you.)

The best way for a Depomed rep to profit from this drug is to keep track of any company direction to sell beyond label, then apply for whistleblower status and rake in a cut of the massive resulting fine. When the track of sales growth doesn't budge in coming months, I predict you'll be told to imply that this isn't really a CII, that it is "safer" than CII alternatives and that the indication means that it works better than drugs to which it was never compared. Sooner or later some non-speaker will drop a dime on you for that and it's game over.

Nearly $60,000,000 in interest payment alone on a brand with less than 3x that in net trade sales. Does someone lack a calculator?
 






Surprise!!!!


Review: could Nucynta cause Renal failure (Acute kidney failure)?

Summary: Renal failure is found among people who take Nucynta, especially for people who are male, 60+ old, have been taking the drug for < 1 month, also take medication Diovan, and have High blood cholesterol.

We study 1,494 people who have side effects while taking Nucynta from FDA and social media. Among them, 9 have Renal failure. Find out below who they are, when they have Renal failure and more.
You are not alone: join a support group for people who take Nucynta and have Renal failure >>>








Nucynta
Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. (latest outcomes from 1,700 Nucynta users)

Renal failure
Renal failure (kidney dysfunction) has been reported by people with high blood pressure, coronary artery bypass, multiple myeloma, diabetes, pain. (latest reports from 72,154 Renal failure patients)

On Apr, 1, 2015: 1,494 people reported to have side effects when taking Nucynta. Among them, 9 people (0.60%) have Renal Failure.
Trend of Renal failure in Nucynta reports
Time on Nucynta when people have Renal failure * :
< 1 month 1 - 6 months 6 - 12 months 1 - 2 years 2 - 5 years 5 - 10 years 10+ years
Renal failure 100.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00%
Gender of people who have Renal failure when taking Nucynta * :
Female Male
Renal failure 0.00% 100.00%
Age of people who have Renal failure when taking Nucynta * :
0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Renal failure 0.00% 0.00% 0.00% 0.00% 0.00% 16.67% 8.33% 75.00%
Severity of Renal failure when taking Nucynta ** :
n/a
How people recovered from Renal failure ** :
n/a
Top conditions involved for these people * :
Blood cholesterol increased (6 people, 66.67%)
Hypertension (6 people, 66.67%)
Dyspepsia (6 people, 66.67%)
Back pain (6 people, 66.67%)
Arthralgia (6 people, 66.67%)
Top co-used drugs for these people * :
Diovan (7 people, 77.78%)
Depakote (7 people, 77.78%)
Baclofen (7 people, 77.78%)
Effexor xr (7 people, 77.78%)
Topamax (7 people, 77.78%)
 






Re: The dog known as NUCYNTA
Old thread but figured some out there might find this useful.

I have nasty cervicogenic headaches and went on Butrans 20mcg/hr. Worked good for the pain and if I were a sales rep this is something I would be pushing as it works well. Unfortunately for me I am part of the fraction of the population that my skin stops absorbing by day five and becomes super irritated. I can't wear the patch for the duration.

So after reading a journal article titled demystifying opioid conversions I asked my doctor for Nucynta. He obliged and wrote me 75mgs q4-6 #120. I tried one while wearing the butrans patch and it was way too much. The statement of it activating the mu receptor seems pretty accurate. I was stoned and didn't like it. So I took off the patch and waited two days to start the nucynta. So then I started the nucynta and it was ok at first. I liked how the patch freed me of pills. Nucynta for management of pain requires very consistent dosing. I found that if I went even a couple minutes over six hours I would feel terrible and it took a couple of consecutive doses prior to feeling better.

The part of it that I could not take was the weird sad depressing thoughts going through my head. Constantly thinking about dead babies and other things just as horrible. I would spend tons of time obsessively reading about mass shootings and other terrible events. This must be the norepinephrine effects of the drug.

In the morning I felt like I slept terribly and my neck and head hurt so bad. Nucynta felt very cold and unpleasant on its own.

After a couple weeks I decided that I had had enough. It may be good for some people that take a mild opiate for the synergistic effects. It in conjunction with an opioid it is not pleasant.

I asked my doc for fentanyl transdermal 12mcg/hr. It takes the pain down to levels that respond to ibuprofen. It does not make me feel like I am on something. I know that my thinking is slightly impaired in the sense that if people speak too fast I have to pause and digest what I heard prior to responding. Better than being angry in pain.

Nucynta made me plenty constipated.

I came across this thread while seeing if I can give nucynta to my geriatric dog for his arthitis. He takes 100mg tramadol ir at a time. Nucynta should work fine for him.
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So it's "locked and loaded" time. The cast and crew of the NUC-boat is set, and it's time to set sail for Get Rich Island. Easy-Peasy.

Let's review the assumptions:
1. J&J's promotion of the brand sucked. It'll be kids' play to outdo it.
2. Quintiles reps' promotion of the brand was half-baked. What a bunch of losers.
3. The DPN indication was never promoted. We'll do so and blow out forecasts.
4. Podiatrists will fall all over themselves to prescribe a CII for painful DPN once we let them know just how great we---er----the drug is.
5. It'll be a cakewalk to get the DEA to reschedule the product. It's a reasonable organization run by reasonable people, and our deep-pocket CII competitors won't bat an eye or try to lobby against it.
6. In the meantime, we'll promote it like it's no more addictive than tramadol, just on the sly...<wink, wink>
7. Given a little help with PA's from our PA-helper people, we'll double market share and double that within 12 months.
8. We'll pre-pay the money we borrowed and our stock price will hit $100.
9. Pfizer will come along and buy the firm for double the market value.

I don't think I've ever seen a firm whose managers knew less about what they bought, but were supremely confident nonetheless. Time to pull up a chair, pop some popcorn and watch the fireworks.
 






STOP your complaining!!! All of you Depomed reps have been so well taken care of. Most of you have been given great territories with high writing docs while the quintiles reps are taking the leftovers and basically have to start over. It is yours to screw up. By the sounds of it, you will screw it up pretty quickly! You have no idea what you are walking into!!
 






Anonymous said:
Anyone with half a brain knows that the value of a DPN indication is priceless. And I firmly believe that Depomed will take this drug to a new level based on that indication only. They have done wonders with a drug with a very narrow window of opportunity based on it's indication (Gralise). It's the right drug for the right company and fits perfectly into their product mix. They'll do a lot better than J and J.
Click to expand...

How stupid could you be? You can use nuerontin generic for pennies instead of paying 400 for Gralse
 
























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